Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centres: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.
The laboratory of Prof. Giuseppe Testa at the Human Technopole (HT) in Milan is looking for a Postdoctoral Researcher funded by the new EU project NEUROCOV (link).
The Testa lab at Human Technopole is a vibrant, interdisciplinary research community spearheading stem cell modelling to study the pathophysiological mechanisms underlying brain diseases across both genetic and environmental causes (Villa et al. Cell Reports, 2022; Caporale et al. Science, 2022; Adamo et al. Nature Genetics, 2015; Mihailovich et al. bioRxiv, 2022; Lopez-Tobon et al. bioRxiv, 2022). At the forefront of human experimental modelling, especially brain organoid technology, the group has been contributing to standard setting benchmarks of the field (Germain et al. Stem Cell Reports, 2017; Pasca et al. Nature, 2022, Lopez-Tobon et al. Stem Cell Reports, 2019; Cheroni et al. Translational Psychiatry in press, 2022), straddling multiple scales of analysis from single cell multi-omics to functional profiling and in vivo validation.
The successful candidate will be part of the NeuroCOV project, a newly established major interdisciplinary research network focused on the neurological and psychiatric consequences of COVID-19, interrogating the host/virus interplay in the human brain at single cell resolution and integrating brain organoid modelling, artificial intelligence and epidemiology to deconvolute personalized trajectories of NeuroCOVID vulnerability and their population impact.
The successful candidate will develop and harness highly innovative experimental model systems to elucidate mechanisms and actionable targets of NeuroCOVID pathogenesis, benefitting from collaborations withing a cutting-edge team of experts from Germany, Italy, Belgium, the Netherlands, Finland, Sweden and Israel. Specifically, they will lead the experimental pipelines (including experimental design, implementation and integrative analysis) to deconvolute personalized trajectories of NeuroCOVID vulnerability in patient-derived brain organoids from longitudinally phenotyped cohorts, combining viral assays, gene editing, single cell multiomic profiling and advanced imaging. To this end, they will harness the state-of-the-art facilities of Human Technopole (Automated Stem Cell and Organoid, Genomics, Light Imaging and Flow Cytometry), and Scientific Support Units (Software Development and Data Curation, Cell Reference Brain Atlas, Tissue Processing, Advanced Cell Culture and Electrophysiology).
Finally, the successful candidate will be responsible for coordinating the computational analysis of the complex datasets produced in the NEUROCOV consortium, performing analysis and/or closely collaborating with the bioinformaticians from the Testa lab and partners, with the aim of integrating molecular and clinical phenotyping and implementing predictive modelling of NeuroCOVID vulnerability.
We are looking for a passionate scientist, eager to apply their critical thinking and creativity to make the difference for one of the most unmet emerging medical needs of our times.
Special consideration will be given to candidates who are part of the protected categories list, according to L. 68/99.
To apply, please send the following:
For any informal inquiry about the position, please feel free to contact Giuseppe Testa at email@example.com (this email address should not be used to send applications)
HT offers a highly collaborative, international culture to foster top quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups with access to outstanding graduate students, postdoctoral fellows and core facilities.
HT is an inclusive employer that fosters diversity and engages systematically to ensure that equal employment opportunities are provided without regard to age, race, creed, religion, sex, disability, medical condition, sexual orientation, gender identity or expression, national or ethnic origin or any other legally recognized status entitled to protection under applicable laws.
HT offers attractive conditions and benefits appropriate to a leading, internationally competitive, research organization that promotes a collegial and open atmosphere.
Number of positions offered: 1
Contract offered: CCNL Chimico Farmaceutico, Employee level, fixed-term
|Location:||Milan - Italy|
|Placed On:||21st December 2022|
|Closes:||10th February 2023|
Type / Role:
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