Research Associate (Neuroscience/alpha-synuclein/iPSC/CRISPR)
University of Cambridge - Cambridge Institute for Medical Research - Clinical Neurosciences
| Location: | Cambridge |
|---|---|
| Salary: | £27,929 to £32,348 or £34,308 - £42,155 |
| Hours: | Full Time |
| Contract Type: | Fixed-Term/Contract |
| Placed On: | 10th January 2023 |
|---|---|
| Closes: | 6th February 2023 |
| Job Ref: | SD34915 |
Applications are invited for a post-doctoral position in the group of Dr Janin Lautenschläger at the Cambridge Institute for Medical Research (CIMR, Biomedical Campus, University of Cambridge). Our lab studies the function of alpha-synuclein, a synaptic protein involved in Parkinson's disease. We have shown that alpha-synuclein undergoes protein phase separation and are now aiming to understand how alpha-synuclein phase separation is regulated and which functional role this plays in synaptic transmission.
The successful candidate would have a strong interest in molecular mechanisms of neurodegeneration and experience with iPSC-derived neuronal cultures including viral transgene expression and CRISPR/Cas9 gene editing. In addition, experience in molecular biology (i.e. molecular cloning, Western blot) and in microscopy are essential. Experience in advanced imaging i.e. FRAP, ratiometric dyes like Synapto-pHluorin, Airyscan, SIM and/or FLIM would be beneficial. We will be starting to work with alpha-synuclein triplication, knock-out and isogenic control iPSC-derived neurons and aim to develop further models to study the functional output of decreased/increased alpha-synuclein phase separation.
A PhD in Molecular Neuroscience (or soon to be awarded) or similar areas is essential. The candidate will be able to independently manage time and experiments to generate data for publication, as supported by a track record of peer-reviewed papers. The candidate will be able to troubleshoot experiments and develop novel research approaches/ideas.
Please submit your C.V. and a cover letter describing how you match the criteria for the post and why you are applying for this role.
Fixed-term: The funds for this post are available for 24 months in the first instance.
We are looking forward to your application, further info can be obtained from Dr Janin Lautenschlaeger jl865@cam.ac.uk .
Please quote reference SD34915 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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