Postdoctoral Researcher in Medicine (Protein Chemistry)

We wish to hire a talented and highly motivated molecular biology postdoc with expertise in protein production, folding and analyses to investigate the translational implications of mechanisms underlying human tissue T cell immune responses funded by the NIHR Biomedical Research Centre.  Graham Ogg’s group is studying lipid-specific T cells in the blood and skin in order to define disease pathogenesis and to identify targets for future therapeutic intervention.  Samples are taken from well-characterised patients seen by Graham Ogg, as a consultant dermatologist.  Lipid-specific and peptide-specific T cells are isolated and analysed through single cell and bulk RNAseq in order to relate clonal T cell populations expressing individual TCR with associated functional responses.  The data will be used to characterise responses to novel antigens, as well as defining the responding T cells and TCR for future therapeutic development, including for inflammatory disease and cancer.  Tissue spatial protein and RNA expression analyses are also being actively pursued.

The successful applicant will hold a PhD in a relevant subject (or close to submission) and will have extensive experience of protein production and analyses, ideally related to HLA molecules and T cell receptors  

The work will be undertaken in the MRC Human Immunology Unit at the Weatherall Institute of Molecular Medicine with collaborative work at other sites across the science campus.

The successful candidate will conduct research in a dynamic and highly collaborative environment of an internationally leading research institute. They will benefit from the institute and wider university expertise in immunology, computational biology, machine-learning and big-data science. There will be opportunities to develop new models to explain differential responses of T cell populations during homeostasis, inflammation and cancer.

The post is full time and fixed term up to 31/03/2025, with the possibility of extension.

Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application.

Only applications received before 12.00 midday on Wednesday 22 February 2023 will be considered.

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