Back to search results

Postdoctoral Research Associate (BBSRC)

University of York - Biology

Location: York
Salary: £34,308 to £39,745 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 1st February 2023
Closes: 21st February 2023
Job Ref: 11865

Role

We are looking for a highly motivated Research Associate to work on a BBSRC-funded project aimed at characterising collisions of the bacterial replication machinery with protein obstacles. This project will exploit the biochemical tractability of Escherichia coli to investigate fundamental aspects of DNA replication at the DNA, protein and complex/super-complex level. The project will focus on studying the mechanistic consequences of replication obstacles for replisomes, resolution of replisome collisions by helicases, and understanding the impact of replication-transcription conflicts on genome duplication. Developing a full molecular understanding of replisome-obstacle collisions is currently a major challenge in the field because they can impede replication fork progression and cause genome instability.

This project will involve a range of methodologies in biochemistry and structural biology, specifically electron cryo-microscopy. The successful applicant will have strong biochemical and structural biology skills alongside a relevant PhD. The ideal candidate would have a background in DNA replication and extensive protein purification experience. This position is full-time and available for 36 months from April 2023 onwards. The starting salary will be within the range £34,308 - £39,745 per annum, depending on relevant experience.

Department

The position will be based in the research group of Dr. Michelle Hawkins within the Department of Biology under the joint supervision of Dr. Michelle Hawkins and Prof. Fred Antson. The Department of Biology is internationally renowned for its research and the successful candidate will benefit from expert training and support from the Bioscience Technology Facility. The structural work will be facilitated by the new Imaging Facility established at the University of York in 2020. This will provide access to the very latest equipment in electron cryo-microscopy and light microscopy, including a 200 kV Glacios cryo-TEM with Falcon IV detector, Zeiss Elyra 7 super-resolution microscope and bespoke TIRF microscope. The Hawkins and Antson groups share interdisciplinary laboratory space and there are multiple opportunities to engage with diverse researchers in the York Structural Biology Laboratory.

Key responsibilities

The main responsibilities are:

  • To conduct research under the supervision of senior colleagues and to contribute to the production of research
  • To assist in the identification and development of potential areas of research and the development of proposals for independent or collaborative research projects

Skills, Experience & Qualifications needed

The successful candidate will have a relevant PhD and strong skills in structural biology and biochemistry. Expertise in protein purification is essential and a background in DNA replication and/or electron cryo-microscopy will be beneficial. In addition candidates should also have:

  • Knowledge of a range of research techniques and methodologies.
  • Research expertise in an area that will complement and enhance the department’s research strategy and goals.
  • The ability to work as part of a team and independently using their initiative.
  • Experience of writing up research work for publication.
  • Willingness to engage in public dissemination of research.
  • Highly developed communication skills (oral and written).
  • The ability to plan and prioritise their own work to meet deadlines.
  • Commitment to personal development and updating of knowledge and skills.

Interview date: TBC

For informal enquiries: please contact Michelle Hawkins at michelle.hawkins@york.ac.uk

The University strives to be diverse and inclusive – a place where we can ALL be ourselves.

We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from University of York

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge