Research Technician in the Circadian Mechanism Underlying Asthma

Job reference: BMH-021221
Location: Oxford Road
Closing date (DD/MM/YYYY): 16/02/2023
Salary: £24,948 to £27,131 per annum, depending on relevant experience
Employment type: Fixed Term
Faculty/Organisation: Biology, Medicine Health
Division: Immunol, Immunity to Infect & Resp Medic
Hours Per Week: 35 hours per week
Contract Duration: From as soon as possible for 12 months
School / Directorate: School of Biological Sciences

We are seeking a highly motivated and organized research technician to join our research group investigating the role of the circadian system in asthma.

The Research Technician will provide technical support with minimal supervision, in a range of project specific research activities including the running and troubleshooting of experiments and maintaining, using and teaching the use of research associated equipment. We are seeking help with the downstream processing of both mouse and human samples from the above studies. Downstream processing will include RNA Sequencing, cytokine bioplex (elisa), histology and immunohistochemistry, flow cytometry, cell culture (development of air liquid interface) and lung slice models. An important aspect of the job will be an ability to work in a team. Our team currently consists of PI (Durrington), PDRAs (Dr Chakraborty and Dr Maidstone), 2 PhD students and several undergraduate and postgraduate students. The technician will be expected to support members of the group, help to supervise and teach undergraduate and postgraduate students. Note keeping, particularly for our human samples is crucial and maintenance of our HTA -80 Freezer. It should be noted that since this is a circadian group some out of hours work (usually evenings or overnight) will be necessary.

To assist team members in ensuring that staff and students operate safe working practices ensuring health and safety compliance within the laboratories.

Applicants should hold a qualification at NQF level 6 (such as a bachelors degree) in a relevant biological science subject or GCSE’s in English and Mathematics (or equivalent) and two additional qualifications at NQF level 3 (at least one of these should be in a Science related subject.) and substantial relevant experience of working in a research laboratory.

Insertion details

Publication(s)  Maidstone RJ, et al. 2021. Night shift work is associated with an increased risk of asthma. Thorax. 2021 Jan;76(1):53-60.

Durrington HJ, et al. 2020. Circadian asthma airway responses are gated by REV-ERBα. Eur Respir J. 2020 Dec 17;56(6):1902407.

Wilkinson M, et al. 2019. Circadian rhythm of exhaled biomarkers in health and asthma. Eur Respir J. 2019 Oct 17;54(4):1901068.

Durrington HJ, et al. 2018. Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and Treatment. Am J Respir Crit Care Med. 2018 Dec 15;198(12):1578-1581.

Carter SJ et al. 2016. A matter of time: study of circadian clocks and their role in inflammation. J Leukoc Biol. 2016 Apr;99(4):549-60.      

Durrington HJ, et al. 2014 The circadian clock and asthma. Thorax. 2014 Jan;69(1):90-2. doi: 10.1136/thoraxjnl-2013-203482.

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status.  All appointments are made on merit.

Our University is positive about flexible working – you can find out more here

Blended working arrangements may be considered          

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:
Name: Dr Hannah Durrington
Email: hannah.durrington@manchester.ac.uk

General enquiries:
Email: People.Recruitment@manchester.ac.uk

Technical support:
https://jobseekersupport.jobtrain.co.uk/support/home

This vacancy will close for applications at midnight on the closing date.

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