Postdoctoral Research Assistant

We are seeking a highlight motivated Postdoctoral Researcher with research experience in functional genomics and / or proteomics to study cell biology / cell signalling, to undertake research in collaboration with one of the leading pharmaceutical companies supporting the Division of Signal Transduction Therapy (DSTT). The DSTT facilitates collaborations between some of the world’s major pharmaceutical companies (Boehringer Ingelheim, GlaxoSmithKline, and Merck-Serono) and leading Dundee-based researchers with a proven track record of achievement in understanding and exploiting the fundamental molecular causes of human disease in the fields of cancer, immune-regulation, neurodegeneration and hypertension resulting from disruptions in protein ubiquitylation, phosphorylation and other signalling networks.

The successful applicant will be based within the Ciulli lab in Dundee (http://www.lifesci.dundee.ac.uk/groups/alessio-ciulli), within the new Centre for Targeted Protein Degradation (CeTPD). The applicant will employ state-of-the-art cell biology, proteomics and biophysical approaches to conduct molecular and functional studies on disease-relevant human Cullin RING E3 ubiquitin ligases. The Ciulli lab has access to facilities available within both the Centre for Targeted Protein Degradation, the Division of Biological Chemistry and Drug Discovery, the MRC Protein Phosphorylation Unit and more widely within the School of Life Sciences. This set-up will ensure the successful candidate will have access to whatever technologies required to conduct the projects th! at they are working on, including molecular, biochemical, mass spec proteomics, pharmacological and genetic methodologies including CRISPR/CAS9 knock-out and knock-in technologies and CRISPR screens. There will be regular opportunity for interaction and to discuss data within the group and with the collaborating pharma company. The post may also provide opportunities for short work placements at the company’s research site.

Requirements:

• PhD in Molecular Biology, Cell Biology, Biochemistry, Proteomics or a related discipline with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
• Strong background in Biochemistry, Molecular Cell Biology, Functional Genomics or Proteomics is required.
• Strong interest in signal transduction research and how modulation of these pathways are linked to human disease is expected.
• Experience with mammalian cells tissue culture and protein-interactions studies inside cells is required.
• Experience with gene editing, gene silencing and generation of stable, knock-in or knock-out cell lines would be highly advantageous.
• Capable of working in a team, but able to plan and work independently.
• Excellent communication skills and knowledge of the English language are essential.
• The candidate should have ambitions to become a successful researcher either in academia or the pharmaceutical/biotechnology industry.

Preferred skills:

• Outstanding academic or industrial track records
• Experience with mass spectrometry-based proteomics and/or CRISPR technologies.
• Experience with working with multi-protein complexes
• Strong data science and computational skills
• Exceptional time management, organisational and self-motivational skills

The funds for this project are available until June 2024 in the first instance, with a chance to renew.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD, in which case the initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale.

Location:

The postholder will be based at the newly refurbished CeTPD Complex at 1 James Lindsay Place, adjacent to the Life Sciences Complex.

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