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PhD Studentship: The Impact of Prolactin to the Neuronal Metabolism

Coventry University - Centre for Sport, Exercise and Life Sciences

Qualification Type: PhD
Location: Coventry
Funding for: UK Students, EU Students, International Students
Funding amount: Fully Funded with Stipend
Hours: Full Time
Placed On: 15th March 2023
Closes: 27th May 2023

Coventry University (CU) is inviting applications from suitably-qualified graduates for a (fully-funded PhD studentship in the Research Centre for Sport, Exercise and Life Sciences (CSELS).

The pituitary lactogenic hormone prolactin (PRL) has well recognized physiological actions in humans and rodents in lactation and reproduction. Accumulating evidence suggests that PRL has a crucial impact on energy and metabolic homeostasis as studies have shown that persistent hyperprolactinemia has emerged as an obesogenic factor. In this sense, the physiological hyperprolactinemia observed in late pregnancy and lactational periods may contribute to the metabolic adaptations to these conditions in the female body. However, whether prolactin has a direct effect on neuronal metabolism requires further investigation.

In collaboration with Dr Mark Turner, Professor Derek Renshaw and Dr Hannah Bridgewater, this project will investigate the impact of prolactin on neuronal metabolism using a hypothalamic cell line subjected to prolactin treatment in vitro and analysing their oxygen consumption. Conditions such as knocking out the PRLR and treatments mimicking the maternal obesogenic environment will also be tested.

The project will provide an opportunity to identify the underlying mechanisms of neuronal metabolism under the effect of prolactin to contribute to the understanding of the central metabolic adaptation that pregnancy and lactation promote to the maternal body.

Entry criteria for applicants to PhD  

  • A bachelor’s (honours) degree in a relevant discipline/subject area with a minimum classification of 2:1 and a minimum mark of 60% in the project element (or equivalent), or an equivalent award from an overseas institution. 
    PLUS  
  • the potential to engage in innovative research and to complete the PhD within 3.5 years 
  • An adequate proficiency in English must be demonstrated by applicants whose first language is not English.  The general requirement is a minimum overall IELTS Academic score of 7.0 with a minimum of 6.5 in each of the four sections, or the TOEFL iBT test with a minimum overall score of 95 with a minimum of 21 in each of the four sections. 

 For further details please visit:  https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/research-entry-criteria/ 

https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/ 

For informal enquires about the project, please contact Dr Isadora Clivatti Furigo (Assistant Professor – research- ad7532@coventry.ac.uk)

Details of all available research opportunities at Coventry University can be found via 

https://www.coventry.ac.uk/research/research-opportunities/ 

All applications require full supporting documentation, and a covering letter – plus one of the following  

For pre-determined (named) projects an up-to 2000-word supporting statement is required showing how the applicant’s expertise and interests are relevant to the project.

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