Research Assistant in Medicinal Chemistry

We seek to recruit an enthusiastic, highly motivated scientist with proven intellectual and technical abilities to work on a 12-month project, Development of di- and triphosphate prodrugs of clofarabine as anticancer agents, funded by Medical Research Council (MRC).

The goal of this project is to acquire key findings to allow the further development of Clofarabine di- and triphosphate phosphoramidate prodrugs as anticancer agents. With this project we will devise a robust scalable prodrugs chemical synthesis to support the manufacturing process, we will assess six selected prodrugs for stability and activation mechanism to prove that upon activation they release the active species, and we will investigate their ability to overcome Clofarabine associated resistance mechanism. From the data collected two lead candidates will be selected for further preclinical investigations (pharmacokinetics and efficacy in vivo studies) to be supported by NuCana.

Further information is available at the following group webpages:
Dr Michaela Serpi: https://www.cardiff.ac.uk/people/view/2484613-serpi-michaela         

For informal enquiries about the role and the Cardiff School of Chemistry, please contact Dr Michaela Serpi, email: SerpiM5@cardiff.ac.uk.

For further details about working at Cardiff University, please contact Dr Mahmoud Akhtar (AkhtarM@cardiff.ac.uk; +44 (029 2087 0680)

This position is full-time (35 hours per week) and is available immediately for 12 months.

To work for an employer that values and promotes equality of opportunity, please visit www.cardiff.ac.uk/jobs and search for vacancy number: 16348BR.

Salary: £29,762 - £34,314 per annum (Grade 5). We do not anticipate that an appointment be made above £31,411 per annum (Grade 5.26).

Important note: It is the University’s policy to use the person specification as a key tool for short-listing. Candidates should evidence that they meet ALL of the essential criteria as well as, where relevant, the desirable. As part of the application process, you will be asked to provide this evidence via a supporting statement.  Please ensure that the evidence you are providing corresponds with the numbered criteria outlined below. Your application will be considered based on the information you provide under each element.

When attaching the supporting statement to your application profile, please ensure that you name it with the vacancy reference number, e.g., Supporting Statement for 16348BR.

Closing date: Wednesday, 19 April 2023

Cardiff University is committed to supporting and promoting equality and diversity and to creating an inclusive working environment. We believe this can be achieved through attracting, developing, and retaining a diverse range of staff from many different backgrounds who have the ambition to create a University which seeks to fulfil our social, cultural and economic obligation to Cardiff, Wales, and the world. In supporting our employees to achieve a balance between their work and their personal lives, we will also consider proposals for flexible working or job share arrangements.

Cardiff University is a signatory to the San Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions we will evaluate applicants on the quality of their research, not publication metrics or the identity of the journal in which the research is published. More information is available at:  Responsible research assessment - Research - Cardiff University

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