Research Associate

Applications are encouraged for a highly-motivated Research Associate to join the laboratory of Dr Iwan Evans in the Department of Infection, Immunity and Cardiovascular disease (https://www.sheffield.ac.uk/medicine/iicd) at the University of Sheffield. We have an exciting opportunity for someone with a passion for cell and developmental biology looking to use their skills in genetics and live imaging to make an impact on inflammation. We use fruit flies (Drosophila melanogaster) to understand macrophage cell biology in vivo.

Through our recent BBSRC-funded project, you will address the mechanisms by which macrophages are retained at sites of inflammation; control of immune cell numbers at these locations has important consequences for a broad range of human pathological conditions including chronic wounds, cancer, neurodegenerative diseases and atherosclerosis.

Using fly genetics and live imaging techniques, you will uncover how macrophages are maintained at wounds, while a proteomic approach will be used to identify novel regulators of this process. This will build upon our recent study published in PLoS Biology (Roddie et al., 2019).

You will possess a PhD in biological/biomedical science (or a related area), previous research experience working with flies (or another relevant genetically-tractable, multicellular model organism) and excellent molecular biology skills. Ideally you will have a background in cell biology, developmental biology or immunology, while standard techniques associated with these fields (such as cell culture, microscopy and immunostaining) and experience handling large datasets (e.g., proteomic or transcriptional profiling data) would also be advantageous. There is a novel proteomic strand to this project, therefore previous experience of proteomics and/or biochemical approaches are essential. An ability to work as part of our team, and to plan, run and analyse your own experiments are also critical.

The Evans lab is part of the Bateson Centre (https://www.sheffield.ac.uk/bateson - a world-leading centre using innovative models to understand human disease, focused around expertise in non-mammalian models) and Helsi – the Healthy Lifespan Institute. We welcome diverse, enthusiastic and collaborative individuals to our team. Engagement with the Think Ahead scheme (https://www.sheffield.ac.uk/faculty/medicine-dentistry-health/thinkahead/ta) will help develop your career and there will be many opportunities for you to present your data internally and externally.

This fixed-term post is available for 3 years. Please do not hesitate to get in contact if you would like to discuss this post ahead of application (i.r.evans@sheffield.ac.uk).

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

To find out what makes the University of Sheffield a remarkable place to work, watch this short film: www.youtube.com/watch?v=7LblLk18zmo.

Apply now by clicking on the Apply button located near the top of your screen.

Advert information