Postdoctoral Research Scientist in Cancer Immunophenotyping

We are seeking to appoint a Postdoctoral Research Scientist to join Professor Elliott’s laboratory at the University of Oxford. You will join a motivated group investigating antigen processing, T cell regulation and immunodominance, and how to utilise this information to develop novel immunotherapies.

The aim of the project is to understand how the immune microenvironment evolves when cancer develops from benign lesions. You will perform immunophenotyping, with a particular focus on T cell affinity, specificity, phenotype and function, on pre-cancer and cancer samples. You will develop and integrate multiparametric flow cytometry pipelines with spatial and transcriptomic readouts to study longitudinal tissue samples; and correlate these with similar measurements made on blood samples collected in parallel. Focus will be on comparing at-risk cohorts (e.g. Barrett’s oesophagus, primary sclerosing cholangitis, liver cirrhosis) with established cancer cohorts (e.g. oesophageal cancer, hepatocellular carcinoma, colorectal cancer).

It is essential that you hold a PhD (or close to completion) in Immunology or related subject, and have experience of and proven research skills in cellular and molecular immunology, including multiplex flow cytometry and T cell culture. You will have experience of in silico analysis of biological data using computational and statistical techniques. It is essential that you are able to demonstrate an active interest in translational research and/or clinical research, and are able to demonstrate excellent communication skills with the ability to communicate results clearly and logically. The ability to manage the day-to-day running of a research project including troubleshooting and a capacity to deliver high quality research outputs, alone or as part of a team, is essential for this role.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract for 3 years and is funded by NIHR BRC Cancer Theme.

Only applications received before 12 midday on 25th April 2023 will be considered. Please quote 164573 on all correspondence.

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