Principal Investigator - UOD483

The newly opened Centre for Targeted Protein Degradation (CeTPD), embedded within the School of Life Sciences at the University of Dundee, is being created as a first of its kind Centre with a focus on fundamental and translational chemical biology in the burgeoning new area of targeted protein degradation (TPD) (www.dundee.ac.uk/cetpd). The overarching goal of CeTPD is to innovate a next-generation of small-molecule technology platforms and modalities to advanc e chemical and biological insights and therapeutic targets related to human diseases. It aspires to achieve this by openly collaborate with academic, industrial and venture partners, and by training and inspiring the next generation of research scientists and leaders who will advance our understanding and translation in this crucial area of research. We also have an interest in developing new approaches and tools to advance proximity-based modalities of chemical intervention akin and beyond TPD.

We invite applications for up to 4 Principal Investigator positions at the tenured or tenure-track level, depending on experience and career stage, and welcome applications from researchers representing all minority groups (see below – “Diversity and equality of opportunity"). The successful applicant would receive CeTPD core support as required including consumables, equipment and access to the world class scientific facilities in the School of Life Sciences. Support and mentorship to competitively apply and secure individual fellowships and grant funding to recruit Postdoctoral Research Assistants and Ph.D. students wil! l be prov ided to successful applicants recruited at tenure-track level.

Who we’re looking for

Applicants should have an exciting research programme aimed at building mechanistic foundations and understanding of targeted protein degradation and related induced-proximity modalities of intervention, and maximising impact in challenging areas of biology of relevance to human disease. We are keen to receive applications from candidates with interest and expertise in all subject areas that might complement and enhance the current work of the CeTPD, and a motivation to enhance the current multidisciplinary work of the CeTPD. We are also interested in applicants with expertise and interest in the following research areas and specific topics:

• Fundamental understanding, at structural and molecular mechanistic level, of how molecular machineries of TPD and induced-proximity modalities works.
• Discovery chemistry, drug design and chemical biology for targeting challenging proteins involved in human disease.
• Functional genomics and proteomics approaches to drive molecular understanding, target validation and enablement of biological systems.
• Enabling chemical, biological, and translational tools to accelerate target validation and pursuit.

Candidate requirements include:

• PhD in a relevant subject
• Proven track record in research and an excellent track record of publications, impact and service
• Significant research programme in the area of targeted protein degradation or induced-proximity research, complementing other research within the CeTPD
• Evidence of ability and willingness to work collaboratively with others
• Ability to write successful grant applications
• Significant knowledge of fundamental and translation chemical and biological research areas.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

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