|Location:||Newcastle upon Tyne|
|Funding for:||UK Students, EU Students, International Students|
|Funding amount:||From £18,662 100% of home tuition fees paid and an annual stipend (living expenses)|
|Placed On:||21st September 2023|
|Closes:||31st October 2023|
Neuromuscular fatigability and exercise intolerance in chronic heart failure
100% of home tuition fees paid and an annual stipend (living expenses) of £18,662.
Successful international candidates will be required to fund the difference between the home fees & international fees.
CHF is a complex clinical syndrome which leads to reduced cardiac output at rest and/or in response to stress. The hallmark symptom of CHF is severe exercise intolerance, which is an integral contributor to impaired quality of life. While the aetiology of exercise intolerance is incompletely understood, impairments along multiple steps of the oxygen transport & utilisation pathway are known to be implicated in lower physical capacity in CHF. One potential contributor to exercise intolerance which has received little attention is neuromuscular fatigability, defined as the reduction in neuromuscular function occurring in response to exercise.
In this PhD, you will characterise neuromuscular fatigability in individuals with CHF and provide insight into its mechanistic determinants. You will assess fatigability & adaptations to exercise training using gold-standard assessments of neuromuscular function during exercise, alongside cardiorespiratory & haemodynamic assessments. Accordingly, this PhD could provide therapeutic targets to improve exercise tolerance and quality of life in CHF.
Number Of Awards: 1
Start Date: 22 April 2024
Award Duration: The funding covers a 3-year PhD
Application Closing Date: 31 October 2023
Newcastle University, Faculty Medical Sciences
Dr Callum Brownstein, School of Biomedical, Nutritional & Sport Sciences
Dr Sarah Charman, Translational & Clinical Research Institute
Professor Djordje Jakovljevic, Translational & Clinical Research Institute
Professor Guy MacGowan, Biosciences Institute
You must have at least a 2:1 honours degree and an MSc or MRes in an appropriate subject, including: exercise science, physiological sciences.
This award is available to home and international applicants. Successful international candidates will be required to make up the difference between home fees and international fees.
English Language requirements: IELTS 6.5 overall, with 5.5 or more in each sub-skill.
How To Apply
To apply for a studentship, you must register and apply through the University’s
Apply to Newcastle Portal, by clicking 'Apply', above.
Once registered select ‘Create a Postgraduate Application’.
Use ‘Course Search’ to identify your programme of study:
You will then need to provide the following information in the ‘Further Questions’ section:
In addition, before you submit your application you will need to upload the following supporting documentation:
For further details, please contact:
Dr Callum Brownstein
School of Biomedical, Nutritional and Sport Sciences
Type / Role: