Research Associate

Contract Type: Fixed term from 1 January 2024 to 31 December 2025

We are seeking an independent and motivated postdoctoral Research Associate to work on projects at the interface of developmental, stem cell and cancer biology. The main project (funded by the Children's Cancer and Leukaemia Group/Little Princess Trust, a close collaboration between the teams of Dr Anestis Tsakiridis and Dr Helen Bryant) focuses on understanding the links between chromosomal copy number variants, DNA damage/repair and neuroblastoma initiation using predominantly human pluripotent stem cell (hPSC)-based models and in vitro differentiation toward trunk neural crest and its derivatives. During the first months of the post, the successful candidate will also work on a second project (the EU H2020-funded Consortium project CONNECT) aiming at the optimisation and development of strategies for generating neural crest-derived components of the enteric nervous system from hPSCs.

Applicants must hold a PhD (or be close to completion/have equivalent experience) in a subject related to stem cell/developmental/cancer biology. Experience in hPSC culture and neural differentiation, immunocytochemistry, flow cytometry, confocal microscopy and qPCR is required. Good knowledge of gain and loss-of-function approaches in hPSCs and DNA damage analysis techniques would be advantageous. The successful candidate will be expected to have excellent interpersonal, written and communication skills, and be able to work to a high standard.

https://www.sheffield.ac.uk/biosciences/people/academic-staff/anestis-tsakiridis

https://www.sheffield.ac.uk/smph/people/clinical-medicine/helen-e-bryant

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