|Funding for:||UK Students|
|Funding amount:||£18,622 for 2023-24|
|Placed On:||29th September 2023|
|Closes:||13th October 2023|
Pathogens transmitted by ticks are responsible for the majority of the vector-borne diseases in temperate North America, Europe and Asia. Concerning Europe, the recent detection of Tick-borne encephalitis across western Europe including the UK, and the spread of Crimea-Congo Fever virus in Spain, Turkey and Albania, rise important public health concern, and emphasize the need of novel vector-based control strategies.
While viral persistence of tick-borne viruses is recognized ecologically, little is known on how tick-borne arboviruses establish viral persistence at the cellular level. Elucidating the determinants essential for initiating and maintaining viral persistence is key for developing vector control strategies and limiting viral transmission. Therefore, the project proposes to develop a novel study system using Ixodes Ricinus cells infected with the tick-borne Flavivirus, Tick-borne encephalitis virus (TBEV), to identify and characterize host factors essential for the viral persistence within vector cells.
Combining system virology tools, gene editing technology and molecular virology methods, you will :
Key Research Objectives:
Tick Cell Biology: Characterize the interactions between Ix. Ricinus tick cells and tick-borne Flaviviruses, with an emphasis on Tick-borne encephalitis virus (TBEV).
Viral Persistence: Investigate the strategies employed by tick-borne Flavivirus to establish and maintain long-term infections within tick cells.
High-Throughput Technology: Utilize state-of-the-art high-throughput technology to analyze large datasets efficiently, enabling a comprehensive understanding of viral-host interactions.
Benefits of the Studentship:
Open to candidates who pay UK/home rate fees. See UKCISA for further information. Starting in January 2024.
You will need to meet the minimum entry requirements for our PhD programme.
We are seeking candidates with a strong background in molecular biology, virology, or related fields. A passion for unravelling the mysteries of tick-borne diseases and a commitment to scientific excellence are essential.
How to apply
Applications should be submitted via the Biosciences and Medicine PhD programme page.
In place of a research proposal you should upload a document stating the title of the project that you wish to apply for and the name of the relevant supervisor.
Please also submit your CV, a cover letter outlining your research interests and motivation, and contact information for two academic referees to firstname.lastname@example.org.
A stipend (£18,622 for 2023-24) and tuition fees covered for 3.5 years.
13 October 2023
Contact Dr Marine Petit, (email@example.com).
Type / Role: