Research Fellow

About us

The mission of the UCL GOS Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

Applications are invited for a Postdoctoral Researcher to join the clinical r! esearch t eam led by Prof Francesco Muntoni at the Dubowitz Neuromuscular Centre, which undertakes high quality research into neuromuscular diseases. You will be responsible for a specific line of collaborative research focused on developing and characterising advanced cellular models of Duchenne Muscular Dystrophy (DMD), collagen 6 related muscular dystrophy (COL6-RD) and myotubular myopathy (MTM) and assess the biodistribution and molecular efficacy of novel therapeutic viral vectors aimed at targeting specific cellular subtypes. You will be involved in generating advanced cellular models of these conditions generating disease specific muscle-on-chip devices, capable of screening cell-specificity of new adeno-associated viral vector (AAV) capsid variants, and unique muscle-specific lentiviruses. The main duties of the post are to work as part of this multidisciplinary consortium and specifically focusing on the conditions indicated above to establish reproducible cellular models, a! ssess the ir differentiation and analytic methods to assess biodistribution and molecular efficacy of the novel viral vectors developed by other partners. The post offers an exciting opportunity for candidates to be involved in a developing area of psychological research within childhood neuromuscular conditions of genetic aetiology. This salary for post is £40,524 pa and this post is available for 36 months.

About you

A PhD in cell and molecular biology or a related discipline is essential. Experience of mammalian cell cultures, protein biochemistry and quantification and RNA analytics is also essential. Familiarity with digital imaging techniques and AAV and or lentiviral vectors is desirable.

What we offer:

Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation, and we! want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusion/ If you have any queries regarding the application process, please contact Madhur Sharma on quoting job reference

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