Postdoctoral Research Associate in Genomics

Location: Hammersmith Campus

Contract: Fixed Term, Full time for 3 years with possibility for extension

Job Summary

Applications are invited for a Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/). We aim to discover fundamental mechanisms that guarantee efficient human DNA replication. The project’s primary objective is to research 1.) how DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2.) how DNA replication is regulated to allow faithful DNA replication. We will ask how mutations in these processes contribute to genome instability and whether they are enriched in cancer.

Who we look for:

We seek a creative researcher who enjoys tackling ambitious research questions. The candidate should enjoy discussing science and be good at networking. This project is ideal for a candidate with prior experience in genomics who wants to explore in a semi-independent way a new research area. Prior experience in the supervision of master students is an advantage. Professor Speck will mentor you in grant writing, networking and publishing. Indeed, the scientific framework and the support means that the candidates are well placed for a successful transition into independence.

Duties and responsibilities

You will perform high-resolution genomics (ChIP-EXO/Cut&Run, bioinformatics analysis, AID, CRISPR). An interest in proteomics and synchronisation of human cells would be beneficial. We are well equipped for genomics (direct access to DNA sequencing facility and bioinformatics team) and proteomics (direct access to excellent local proteomics facilities).

Essential and requirements

• PhD & a strong publication record (published or submitted)
• Expertise in mammalian cell culture
• Extensive practical expertise in a broad range of techniques, including ChIP, ChIP-seq (ideally ChIP-EXO/Cut&Tag) and library preparation
• Expertise in bioinformatic analysis
• Ability to troubleshoot and work independently
• Background in nucleic acid-protein interactions, cell-cycle, chromatin-biology, transcription, kinase-regulation, molecular-machines, or genome-stability.

Further Information

This is a Full Time and fixed-term role for 3 years initially based at the Hammersmith Campus.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £40,694 - £43,888 per annum.

Should you require further information please contact: Christian – chris.speck@imperial.ac.uk.

For technical issues when applying online please email support.jobs@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/ 

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

Closing date: 14.11.2023

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