Back to search results

PhD Studentship: Development of a Microfluidic Platform for Identification of NSCLC Patients at Higher Risk for Brain Metastasis

University of Plymouth

Qualification Type: PhD
Location: Plymouth
Funding for: UK Students, EU Students, International Students
Funding amount: £18,110 per annum 2023-24 rate
Hours: Full Time
Placed On: 20th October 2023
Closes: 15th February 2024

DoS: Dr. Mahmoud Labib (Mahmoud.labib@plymouth.ac.uk, tel.: 0747 121 3967)

2nd Supervisor: Prof. Dr. Oliver Hanemann (oliver.hanemann@plymouth.ac.uk, tel.: 0175 258 3240)

3rd Supervisor: Dr. Elizabeth Lim (elizabeth.lim@nhs.net, tel.: 0175 243 2338)

4th Supervisor: Dr. Matthew Jones (Matt.jones-32@plymouth.ac.uk, tel.: 0175 243 2338) 

Applications are invited for a three-year PhD studentship. The studentship will start on 1st April, 2024. 

Project Description

Non-small cell lung cancer (NSCLC) accounts for 80% of patients with primary lung cancer. Up to 55% of the patients with advanced NSCLC develop brain metastases (BM) with a median survival of 2–3 and 4–6 months in untreated and treated patients, respectively. Due to the location of metastatic lesions, surgical resection is limited, and chemotherapy is quite ineffective due to the blood brain barrier (BBB). It is thus crucial to identify patients at higher risk for BM at an early stage. BM has been ascribed to the presence of competent subsets of circulating tumour cells (CTCs) that transmigrate through the BBB and thrive in the brain. No definitive signature genes for BM have been identified in CTCs from NSCLC due to the lack of validated markers or strategies to isolate these cells with high-efficiency enrichment to facilitate subsequent gene expression profiling. We will deploy a microfluidics-based cell sorting platform to isolate CTCs from a cohort of NSCLC patients with BM. Isolated CTCs will be subjected to comprehensive gene expression profiling to identify the signature genes of BM. Gene ontology will be used to identify the involved molecular pathways and cellular functions of identified signature genes. A microfluidics-based cell profiling platform will be developed to analyse the proteins encoded by the signature genes in CTCs collected from NSCLC patients and subsequently identify patients at higher risk form BM. 

Eligibility 

Applicants should have a first or upper second class honours degree in an appropriate subject or a relevant Masters qualification. If your first language is not English, you will need to meet the minimum English requirements for the programme, IELTS Academic score of 7.0 (with no less than 6.5 in each component test area) or equivalent. 

The studentship is supported for 3 years and includes full Home tuition fees plus a stipend of £18,110 per annum 2023-24 rate. The studentship will only fully fund those applicants who are eligible for Home fees with relevant qualifications. Applicants normally required to cover International fees will have to cover the difference between the Home and the International tuition fee rates (approximately £12,697 per annum 2023-24 rate). 

NB: The studentship is supported for three years of the four-year registration period. The fourth year is a self-funded ‘writing-up’ year. 

If you wish to discuss this project further informally, please contact Dr. Mahmoud Labib, mahmoud.labib@plymouth.ac.uk

To apply for this position please visit here. 

Please clearly state the name of the studentship that you are applying for on the top of your personal statement. 

Please see here for a list of supporting documents to upload with your application. 

For more information on the admissions process generally, please visit our How to Apply for a Research Degree webpage or contact the Doctoral College

The closing date for applications on 15th February 2024. Shortlisted candidates will be invited for interview shortly after the deadline.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Plymouth

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge