Back to search results

Research Associate (ER-mitochondria Signaling as a Therapeutic Target for Dementia)

King's College London - Basic & Clinical Neuroscience - IoPPN

Location: London
Salary: £42,405 to £49,785 per annum, including London Weighting Allowance.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 17th November 2023
Closes: 8th January 2024
Job Ref: 078665
 

Location: Denmark Hill Campus. Category: Research.

Job description

Applications are invited for a postdoctoral research associate to be based in the Department of Basic and Clinical Neuroscience at King’s College London. The post is funded by the Alzheimer’s Research UK for at least 18 months and will investigate the role of defective endoplasmic reticulum (ER)-mitochondria signaling in dementia and amyotrophic lateral sclerosis (ALS). ER-mitochondria signaling and its role in dementia/ALS are highly topical areas of research and the grant holders have made major contributions to these fields. The successful applicant will join a multi-disciplinary group that seeks to understand the mechanisms by which ER-mitochondria signaling is perturbed in dementia/ALS and how correcting damaged ER-mitochondria signaling might be therapeutic for these major diseases. 

The post will focus on how the Sigma-1 receptor affects ER-mitochondria tethering and signaling, and how novel compounds that target ER-mitochondria tethering proteins might in have therapeutic potential for dementia and ALS. Experience in cell and molecular biology approaches including advanced light microscopy and experimental manipulation of neurons would be advantageous. Knowledge of defective signaling processes in dementia and related disorders will also be useful. You will join an established research group and will have access to state-of-the-art facilities in both King’s College and the King’s College Dementia Research Institute. For further information on our work see https://kclpure.kcl.ac.uk/en/persons/christopher-miller

This post will be offered on a full-time, fixed term contract for 18 months.

Key responsibilities
  • To use cell, molecular and advanced microscopy approaches to understand the roles that the Sigma-1 receptor has on ER-mitochondria tethering proteins and signaling functions, and to probe the therapeutic benefits of Sigma-1 receptor agonists in cell models of dementia and ALS.  
  • To use cell, molecular and advanced microscopy approaches to understand the roles that novel small molecules that we have identified have on ER-mitochondria tethering proteins and signaling functions, and to probe the therapeutic benefits of these molecules in cell models of dementia and ALS. 
  • To conduct literature reviews and contribute to publications arising from this project. 
  • Attend and as appropriate, present research findings and papers at internal and external academic meetings and external professional conferences, and to contribute to the internal and external visibility of the departments and group. 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from King's College London

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge