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Research Fellow

UCL - Development Biology and Cancer Programme

Location: London
Salary: £40,524 to £46,232 per annum, inclusive of London Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 20th November 2023
Closes: 5th January 2024
Job Ref: B02-06098

About us

The mission of the UCL Great Ormond Street Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health.

About the role

This new post represents an opportunity for an experienced post-doctoral research fellow to develop their expertise as a senior Good Manufacturing Practice (GMP) production scientist who will lead production campaigns to therapeutic CAR-T cell products for children with malignant brain tumours. The post will comprise approximately one year of developing and performing validation runs and preparing documentation for regulatory submission, followed by two years of leading a team in manufacturing campaigns. The job represents a significant opportunity for a scientist with experience in GMP manufacturing to consolidate their expertise or for an experienced post-doctoral researcher to develop and implement new skills in GMP for cell and gene therapy. There is considerable opportunity for the appointee to develop or consolidate a longer-term career in GMP for cell and gene therapy and to interact collaboratively with the preclinical team in further academic GMP manufacturing development. The salary offered in this post is £40,524 - £46,232 per annum and is funded for 3 years in the first instance.

About you

The successful candidate will have a PhD in the biomedical sciences and previous experience of cell and gene therapies as well as a working knowledge and understanding of the regulatory aspects of working within a GMP facility. We particularly welcome applicants who have previous hands-on experience of working within an accredited GMP facility and who have detailed knowledge of HTA and MHRA regulations. Consideration will be given to applicants who lack direct GMP experience but who are experienced in working with human T cells and viruses and who have demonstrable team leadership and management skills.

What we offer

As well as the exciting opportunities this role presents we also offer some great benefits some of which are below: 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days) Defined benefit career average revalued earnings pension scheme (CARE) Cycle to work scheme and season ticket loan On-Site nursery On-site gym Enhanced maternity, paternity and adoption pay Employee assistance programme: Staff Support Service Discounted medical insurance.

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