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Do class I HDAC inhibitors have the potential to arrest the progression of type 1 diabetes?

University of Exeter - Faculty of Health and Life Sciences

Qualification Type: PhD
Location: Exeter
Funding for: EU Students, International Students, Self-funded Students, UK Students
Funding amount: The studentship will cover UK tuition fees plus an annual tax-free stipend of £18,622.00 for 3 years full-time, or pro rata for part-time study.
Hours: Full Time
Placed On: 23rd November 2023
Closes: 2nd January 2024
Reference: 5009

Project description:

Type 1 diabetes (T1D) is caused by the selective destruction of insulin producing beta-cells. This process is mediated by autoreactive immune cells which erroneously target beta-cell proteins. Immune cells detect their targets through interaction with the major histocompatibility complex class I (MHC-I) which is found on the surface of all cells. However, the levels of this complex are dramatically increased on beta-cells during T1D development, thereby increasing the visibility of these cells to the immune system and expediting disease progression. Thus, targeting of the mechanisms which underpin MHC-I ‘hyper-expression’ may be beneficial to individuals with T1D.

Fees and funding:

For eligible students, the studentship will cover Home tuition fees plus an annual tax-free stipend of at least £18,622 (in alignment with standard Research Council UK rate) for 3 years full-time, or pro rata for part-time study, in addition to a Research Training and Support Grant (RTSG). The student would be based at the Research, Innovation, Learning and Development (RILD) building based at the Royal Devon and Exeter Hospital site in Exeter, near to the St Luke’s campus.

*Students who pay international tuition fees are eligible to apply, but should note that the award will only provide payment for part of the international tuition fee and no stipend. International applicants need to be aware that you will have to cover the cost of your student visa, healthcare surcharge and other costs of moving to the UK to do a PhD.

The conditions for eligibility of home fees status are complex and you will need to seek advice if you have moved to or from the UK (or Republic of Ireland) within the past 3 years or have applied for settled status under the EU Settlement Scheme.

Timeline:

The closing date for applications is midnight on Tuesday 2nd January 2024.

Interview panels will be held virtually in late January/ early February 2023 for a September 2024 start.

Contact details:

If you would like to discuss the studentships further, please contact the primary supervisor as stated in the advert. If you have any queries surrounding the application process or the BRC more generally, please contact Dr Sophie Gould (NIHR Exeter BRC Training and Events Manager) at S.L.Gould@exeter.ac.uk.

Entry requirements:

Applicants for this studentship must have obtained, or be about to obtain, a First or Upper Second Class UK Honours degree, or the equivalent qualifications gained outside the UK, in an appropriate subject area.

How to apply:

In the application process, you will be asked to upload several documents:

  • CV – all aspects below must be included, if applicable.
  • Contact details
  • Education history
  • Work history
  • Work experience (voluntary and/ or paid)
  • Professional development and skillset e.g. certification, courses, workshops, conference attendance/ presentations
  • Publications and awards
  • Letter of motivation (maximum 2 pages)
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