|From £41,935 with benefits, subject to skills and experience
|23rd November 2023
|22nd January 2024
The Tapon lab studies the control of tissue and body size during development and evolution. How do cells in a developing organism stop growing and dividing when the correct body size and shape has been reached? How is the appropriate tissue architecture generated during development to produce functional organs? These fundamental biological questions have clear implications for cancer, where cells lose the ability to respond to tissue size boundaries, and for regenerative medicine, where the proliferative potential of quiescent cells must be unleashed in a controlled manner.
We are seeking a motivated postdoctoral scientist who will investigate the cellular and molecular mechanisms of organ size evolution using the abdominal epidermis of fruit flies of the Drosophila genus species as model systems.
We have developed state-of-the-art live-imaging, analytical and modelling tools that enable us to directly track developmental growth of the Drosophila melanogaster adult abdominal epidermis and unravel the regulatory inputs that dictate tissue size (PMID: 35167804). The successful candidate will take advantage of the broad variation in abdomen sizes across the Drosophila genus and the precision of our quantitative approach to developmental growth in the abdominal epidermis to explore tissue size control in differently sized Drosophila species. We will ask what cellular behaviours and molecular mechanisms underpin the evolution of organ size. Using cutting-edge gene editing techniques, we will create genetic tools in several species of different sizes and perform a comparative quantitative developmental biology approach to understand the cellular basis of abdomen size differences across species. Using comparative transcriptomics and knowledge gained from our work on size control in the Drosophila melanogaster abdominal epidermis, we will identify the molecular mechanisms that drive the evolution of tissue size.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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