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Postdoctoral Research Scientist

University of Oxford

Location: Oxford
Salary: £44,263 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 27th November 2023
Closes: 5th January 2024
Job Ref: 169660

Fixed-term for 17 months, Full-time

An opportunity is offered for an ambitious and enthusiastic candidate to work as a postdoctoral research assistant in the group of Prof. Manuela Zaccolo on a project focused on the role of cAMP nanodomain signalling in cardiac pathophysiology. The post is ideally suited to a postdoctoral scientist with experience in biochemical techniques applied to the study of protein-protein interactions and with experience in cell and molecular biology methods.

The successful applicant will take a leading role in analyzing nanodomain cAMP signalling in normal and diseased cardiac myocytes. The project will investigate the link between localised cAMP signalling and functional effects and aim at developing strategies for selective local manipulation of cAMP levels to affect specific function. In particular, the project will involve application of biochemical approaches to identify protein interacting partners of key components of the cAMP/PKA signalling pathway and to elucidate the impact that different phosphodiesterase isoforms have on cardiac myocyte function.

Duties include managing own academic research involving small-scale project management and act as a source of information to other members of the group; adapting existing and developing new scientific techniques and experimental protocols; testing hypotheses and analysing scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate; contributing ideas for new research projects and developing ideas for generating research income.

You will have a strong background in molecular biology techniques (cloning, mutagenesis, primer design) and biochemistry, protein purification and analysis, in particular with regard to protein-protein interactions. Applicants must hold, or be close to completion of, a PhD/DPhil in a relevant area of research and have experience with handling hiPSC and differentiation into cardiac myocytes.

This fixed-term post is available for 17 months to start from 2nd of March 2024. The post will be based in the Department of Physiology Anatomy & Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT.

Informal enquiries may be directed to the DPAG HR Team – hr@dpag.ox.ac.uk/Professor Manuela Zaccolo – manuela.zaccolo@balliol.ox.ac.ukDetails of “how to apply” can be found in the accompanying job description.

Closing date for applications is midday on 5th of January 2024.

Interviews are likely to be held in the week commencing 22nd of January 2024.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion

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