|From £41,935 with benefits, subject to skills and experience
|28th November 2023
|27th January 2024
Location: The Francis Crick Institute, Midland Road, London
The Tapon lab studies the control of tissue and body size during development. How do cells in a developing organism stop growing and dividing when the correct body size and shape has been reached? How is the appropriate tissue architecture generated during development to produce functional organs? These fundamental biological questions have clear implications for cancer, where cells lose the ability to respond to tissue size boundaries, and for regenerative medicine, where the proliferative potential of quiescent cells must be unleashed in a controlled manner.
Our goal is to understand how a diverse set of cues acting at the local, tissue autonomous level (e.g. mechanical forces, tissue architecture, developmental signalling pathways) are integrated with systemic signals (e.g. nutrient availability, hormones) to determine final animal size. Our lab combines live-imaging and quantitative developmental biology approaches to unravel the dynamics and regulatory inputs of developmental growth in Drosophila with in-depth exploration of the molecular mechanisms that underpin this process in fly and mammalian cells.
The successful applicant will use genomic/metabolomic, as well as candidate approaches to discover the molecular nature of these signals. With cutting-edge imaging and optogenetic tools, they will unravel how these inputs work together to signal timely growth termination. We are particularly interested in understanding how a diverse set of cues acting at the local, tissue autonomous level (e.g. mechanical forces, tissue architecture, developmental signalling pathways) are integrated with systemic signals (e.g. nutrient availability, hormones) to determine final tissue size.
Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
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