Back to search results

Postdoctoral Fellow - N Tapon Lab

The Francis Crick Institute

Location: London
Salary: From £41,935 with benefits, subject to skills and experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 28th November 2023
Expires: 27th January 2024
Job Ref: R1403
 

Location: The Francis Crick Institute, Midland Road, London

Short summary 

The Tapon lab studies the control of tissue and body size during development. How do cells in a developing organism stop growing and dividing when the correct body size and shape has been reached? How is the appropriate tissue architecture generated during development to produce functional organs? These fundamental biological questions have clear implications for cancer, where cells lose the ability to respond to tissue size boundaries, and for regenerative medicine, where the proliferative potential of quiescent cells must be unleashed in a controlled manner. 

Our goal is to understand how a diverse set of cues acting at the local, tissue autonomous level (e.g. mechanical forces, tissue architecture, developmental signalling pathways) are integrated with systemic signals (e.g. nutrient availability, hormones) to determine final animal size. Our lab combines live-imaging and quantitative developmental biology approaches to unravel the dynamics and regulatory inputs of developmental growth in Drosophila with in-depth exploration of the molecular mechanisms that underpin this process in fly and mammalian cells.

Key Responsibilities

The successful applicant will use genomic/metabolomic, as well as candidate approaches to discover the molecular nature of these signals. With cutting-edge imaging and optogenetic tools, they will unravel how these inputs work together to signal timely growth termination. We are particularly interested in understanding how a diverse set of cues acting at the local, tissue autonomous level (e.g. mechanical forces, tissue architecture, developmental signalling pathways) are integrated with systemic signals (e.g. nutrient availability, hormones) to determine final tissue size. 

Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

  • If you are interested in applying for this role, please apply via our website, by clicking on the 'Apply' button above.
  • There is no end date for this role; the position will remain open until suitable candidates are found
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from The Francis Crick Institute

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge