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Research Associate in Microbial Biophysics

University of York - Department of Chemistry

Location: York
Salary: £36,024 to £44,263 per year.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 29th November 2023
Closes: 10th January 2024
Job Ref: 12901

Department
A research associate post is available for up to 42 months in the York Structural Biology Laboratory, part of the Department of Chemistry; working in the group of Dr Jamie Blaza, a UKRI Future Leader Fellow, on the BBSRC sLoLa-funded project ‘Understanding an ancient universal membrane effector system’. The role is interdisciplinary, integrating biophysics, microbiology and biochemistry.

You will investigate the structure and mechanisms of important respiratory chain complexes both in, and isolated from, Bacillus subtilis. You will use functional biophysical assays, electron cryo-microscopy (cryoEM), and microbiology to understand the mechanism of these complexes, how they integrate into the biology of the organism, and how these processes might be attacked to develop new antibiotics.

The Department of Chemistry is one of the largest and most successful departments at York and we are renowned internationally for our research. As a department, we strive to provide a working environment that allows all staff and students to contribute fully, to flourish, and to excel. We are proud of our Athena SWAN Gold Award.

Role

  • To conduct research under the supervision of senior colleagues, specifically to:
    • Grow and maintain Bacillus subtilis cultures in different defined growth conditions to induce specific bioenergetic systems.
    • Isolate the membrane-bound respiratory enzymes of interest in intact, active states.
    • Carry out biochemical characterisation of enzymes using both routine analytical techniques and specialised biophysical assays.
    • Subject isolated enzymes to high-resolution cryoEM.
    • Combine different types of data to build a comprehensive understanding of how the bioenergetic system of B. subtilis powers the organism in different growth conditions.
    • Use knowledge gained and results from other members of the research consortium to understand how LiaH IM30 proteins protect bioenergetics.

Where appropriate you will:

  • Assist in the identification and development of potential areas of research and research proposals.
  • Provide guidance to other staff and students, as well as coordinate the work of small research teams.
  • Analyse and write up research results and disseminate them through publications, seminar and conference presentations, public engagement and outreach activities.
  • Assist with undergraduate teaching in own area of expertise.

Skills, Experience & Qualification needed

  • A first degree in a discipline related to molecular sciences.
  • PhD and experience of carrying out independent and collaborative research in biochemistry, biophysics, bacteriology, or a related field.
  • Knowledge of biophysical methods, such as cryoEM.
  • Competence at routine biochemical/microbiological techniques.
  • Have, or will shortly have, published rigorous scientific findings and the ability to explain how these findings advance their field.
  • Highly developed oral and written communication skills including presenting at conferences.
  • Ability and experience to develop research objectives, carry out individual and collaborative projects, planning and prioritising own work to meet deadlines.
  • Highly motivated and professional with collaborative work ethic, committed to high quality research and a willingness to proactively support colleagues and students.
  • Ability to work within a team and independently using own initiative with attention to detail.
  • Understanding of and commitment to Equality and Diversity.

Interview date: TBC

For informal enquiries: please contact Dr Jamie Blaza, jamie.blaza@york.ac.uk.

The University strives to be diverse and inclusive – a place where we can ALL be ourselves.

We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.

We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork

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