|Newcastle upon Tyne
|£33,966 to £37,099 per annum
|6th December 2023
|12th January 2024
We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.
We are looking for an experienced postdoctoral Research Associate to join Prof Sophie Hambleton, Dr Chris Duncan and team at the NU Translational and Clinical Research Institute, Newcastle University.
You will be responsible for the delivery of MRC-funded research on direct and indirect pathogenic properties of type I interferon (IFN-I) in the CNS, providing a framework for interpreting pathomechanism in neurodegenerative disease. This project explores the cellular drivers of IFN-mediated pathology using conditional in vivo expression of the pathogenic allele in individual cell types, allied with human induced pluripotent stem cell (hiPSC) models of the corresponding cell types in vitro. We will also assess novel IFN-I inhibitors developed in partnership with medicinal chemistry collaborators.
A PhD in a relevant field (such as immunology or neuroscience) and experience of pre-clinical models (Home Office personal licence) will be required and some experience of working with stem cell derived cells and/or primary brain slice cultures would be advantageous.
You will have advanced skills in some or all of: molecular biology, neuropathology, fluorescence microscopy, tissue culture, protein biochemistry and cellular immunology including techniques pertinent to innate immunity. Applicants should demonstrate a high level of analytical and problem solving capability and you will need to communicate complex information with clarity. You should be in a position to bring individual skills and insights to the research, for example suggesting ideas, methodologies and interpretations.
This is a full time post (37 hours per week) fixed term for 12 months, with the potential for extension.
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