|UK Students, EU Students, International Students
|8th December 2023
|12th January 2024
The AIM (Advanced Inter-Disciplinary Models) DTP is funded by the MRC between three Partners – the Universities of Birmingham, Leicester and Nottingham – and three more Associate Partners – the Research Complex at Harwell, Mary Lyon Centre and Rosalind Franklin Institute. We have a range of exciting and diverse PhD 4-year projects at all 3 partner Institutions which are now open for a September 2024 start and those available at The University of Nottingham are detailed below.
Projects with an industry partner (iCASE projects) offer a unique opportunity to undertake translational research and come with a mandatory placement requirement and an enhanced stipend.
Full information about funding of these projects and application details, including application form plus Equality, diversity and inclusion form are available at https://more.bham.ac.uk/mrc-aim/phd-opportunities/.
The deadline for submitting applications is 12.00 am GMT, Friday, 12 January 2024. Interviews will take place during the week commencing 26 February and will be held via Zoom.
Applicants must hold, or be about to obtain, a First or Upper Second class UK honours degree, or the equivalent qualifications gained outside the UK, in a relevant subject. A master’s qualification in a related area could be beneficial, as could additional relevant research experience.
Full details can be found on the MRC website.
Please submit your application for University of Nottingham projects to RA-DTPemail@example.com .
School of Medicine
Project Title Leveraging genetics to identify drug targets for respiratory disease
Supervisors Professor Ian Sayers, Ian.firstname.lastname@example.org
Dr Robert Hall (UoN), Professor Louise Wain (Leicester), Dr Nick Shrine (Leicester)
We have made significant advances in identifying genetic variants that increase the risk of lung function impairment and chronic obstructive pulmonary disease (COPD), including recently 26 genetic variants that are potentially deleterious to protein structure/function.
The aim of this PhD studentship is to focus to these potential deleterious coding variants/genes and use a combination of genetic epidemiology, molecular biology, primary cell/tissue models to provide insight into disease mechanisms and identify potential therapeutic opportunities.
We will investigate predictive models for the impact of variants on protein structure. Candidate genes will be prioritised for functional work based on predicted protein alterations, single cell and spatial gene and protein expression profiling and scope for targeting by drugs. We will prioritise a subset of candidates for functional evaluation in a series of in vitro models ranging in complexity including primary cell, multicellular, lung tissue models in combination with genome editing to understand the role of the proteins and variant proteins in cell homeostasis and initiate studies to target altered mechanisms.
This studentship is part of a collaboration involving the Universities of Nottingham, Leicester, and Cambridge and will include training and skills development in genetic epidemiology, bioinformatics, genome editing, molecular biology, cell biology and imaging.
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