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Research Fellow

UCL - Division of Infection and Immunity

Location: London, Hybrid
Salary: £42,099 to £50,585
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 15th February 2024
Closes: 6th March 2024
Job Ref: B02-06481

About us

A position exists for a post-doctoral Research Fellow in the laboratory of Professor Lucy Walker in UCL’s Division of Infection and Immunity (Royal Free campus).

The Division of Infection & Immunity is the focus for research and teaching in infection, immunity and inflammation. The post will be based in the UCL Institute for Immunity & Transplantation in the Pears Building on the Royal Free Hospital site. Work within the Institute aims to improve our mechanistic understanding of the immune system and to translate research advances into improved diagnosis and therapy. By embedding high quality basic research programmes within a hospital environment, the Institute provides an excellent interface between science and medicine.

The incidence of autoimmune diseases is increasing and these disorders affect around 8% of the European population. This has significant implications for quality of life and poses an increasing burden on healthcare resources. The Walker group aims to understand how the immune system is normally regulated to prevent the initiation of autoimmunity.

About the role

The post holder will undertake a project to study how self-reactive T cells respond to encounter with self antigen, using a range of in vivo models and techniques. We are particularly interested in how costimulatory pathways influence the fate trajectories of self-reactive T cells and the role of the CD28/CTLA-4 pathway in this process. In some settings, self-reactive T cells may differentiate into follicular helper T cells whereas in other scenarios they may adopt a regulatory T cell (Treg) fate. Overall the project seeks to understand the signals that control the responses of self-reactive T cells and how this influences the development of autoimmune diseases.

The selected applicant will join a successful, well-funded, mixed-nationality research group that aims to characterise how the immune system remains tolerant to our own body. The post holder will be expected to perform research under the direction of the Principal Investigator and to work collaboratively with other group members.

The position is funded for 24 months in the first instance with a start date of 1st May 2024.

The advert will close on 06/03/2024 at 23:59 GMT.

Proposed interview date: 19th March / 25th March 2024.

About you

The post holder should have a PhD (or about to be awarded) in a relevant research area.

The successful candidate will have experience in in vivo work and multi-parameter flow cytometry as well as competency in the analysis of immune cells. Experience in immune regulation research is desirable.

Note: Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Grade 6B (£37,322 - £39,980 per annum) with payment at Grade 7 (£42,099 - £50,585 per annum) being backdated to the date of final submission of the PhD thesis. Salaries are inclusive of London Allowance.

What we offer

As well as the exciting opportunities this role presents, we also offer great benefits. Please visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.

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