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Postdoctoral Research Scientist

University of Oxford - Department of Physiology, Anatomy and Genetics

Location: Oxford
Salary: £36,024 to £44,263 per annum : Grade 7
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 16th February 2024
Closes: 15th March 2024
Job Ref: 171179

Full-time/Fixed term for 2 years 

Applications are invited for a Post-Doctoral neuronal cell and molecular biologist to work on a new project to develop a novel gene therapy for Parkinson’s in patient stem cell-derived neurons. The project, in collaboration with Kaleibe Therapeutics and Replay (https://replay.bio), represents an exciting opportunity to undertake translation work into biological therapeutics at the interface between academic and industrial research in an exceptional setting. This work will develop novel gene therapies for Parkinson’s by expression of complete genomic DNA transgenes from HSV1 viral vectors to correct cellular phenotypes in induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s patients.

Duties will include the design, generation and delivery of HSV1 gene expression vectors to in vitro models of Parkinson’s to study phenotypic correction; maintenance and differentiation of iPSC-derived neurons and cell lines; undertaking laboratory experiments; interpretation of data; imaging analysis; preparation of data for publication; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of neuronal cell cultures and DNA gene expression plasmid vectors, and a good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential.

Applicants must hold, or be near completion of, a PhD in a relevant area of research and have experience in cellular neuroscience or molecular cell biology relevant to analysis of neuronal phenotypes in vitro and in vivo.

The post is available for two years to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT

Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).

Closing date for applications is midday on Friday 15th March 2024. Interviews are likely to be held the week beginning 25th March 2024.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.  

While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements. 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion  

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