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Stem Cell Research Assistant

King's College London - Basic & Clinical Neuroscience - IoPPN

Location: London
Salary: £37,332 per annum, including London Weighting Allowance.
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd February 2024
Closes: 10th March 2024
Job Ref: 084933
 
Job description

The post holder will carry out research into understanding how pro-inflammatory cytokines impact the form and function of glia and neurons. The project will involve the characterisation of novel induced neural cell cultures using gene-edited human induced pluripotent stem cells (hiPSCs). Research will focus specifically, but not exclusively, on establishing co-cultures between iNeurons and iMicroglia, before assessing the impact of specific cytokines on cell cultures of isolated- and co-cultured neural cells. You will be expected to carry out routine experiments required for these studies. You will be required to grow and manipulate human stem cells and induced neural and glial cultures using aseptic techniques and to perform a range of techniques, including immunocytochemistry, microscopy, molecular biology and electrophysiology (multi-electrode arrays). You will also be expected to work with researchers within the group, including PhD students and post-doctoral fellows. Experience of working with hiPSCs/stem cells is essential.  

This post will be offered on an a full-time, fixed-term contract up to 31st March 2025. 

Key responsibilities
  • Develop and undertake research of high quality consistent with making a full active research contribution in line with the departmental research strategy.  
  • Grow and maintain multiple human induced pluripotent stem cell lines. 
  • Differentiate human induced pluripotent stem cells into specific neural linages and glial cells. 
  • Establish co-cultures of multiple neural cell lines with glial cells. 
  • Perform immunohistochemcial, molecular, and cellular biochemistry studies to discover and understand the cellular, electrophysiological and molecular phenotypes associated with pro-inflammatory cytokine signalling. 
  • Carry out data collection, analysis and archiving. 
  • Conduct literature reviews and contribute to publications arising from this project. 
  • Attend and as appropriate, present research findings and papers at internal academic meetings. 
  • Facilitate collaboration and networking which engages and supports the activates of the Department. 
  • Undertake any other reasonable duties that may be relevant to the role outline including supporting other group members. 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  

Skills, knowledge, and experience  

Essential criteria  

  1. Hold a relevant master’s degree (e.g. degree in neuroscience) or be close to completion
  2. Experience in tissue culture, growth and maintenance of (human) neuronal/stem cell cultures
  3. Experience of immunocyto/histochemical techniques
  4. Experience of working in a research team as well as independently 

Desirable criteria

  1. Experience in differentiating iPSC cells using a forward programming approach
  2. Experience in basic molecular biology
  3. Experience of electrophysiological techniques and analysis
  4. Have a high level of organizational skills 
Further information

This is a collaboration with a commercial partner and the post holder will be expected to collaborate with the scientists from this company.

Closing date: 10th March 2024

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