Location: | Dundee |
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Salary: | £36,024 to £44,263 |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 8th April 2024 |
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Closes: | 3rd May 2024 |
Job Ref: | 4015 |
We are recruiting for an exceptional Structural Biologist / Biophysicist with experience in studying structures of protein- ligand and protein-protein complexes to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee. This position is part of an academic, multi-disciplinary drug discovery team being formed within the Ciulli group, funded by the Cancer Grand Challenges, within KOODAC (https://cancergrandchallenges.org/teams/koodac). KOODAC’s mission is to discover and develop small-molecule drugs that degrade key oncogenic drivers of solid tumours in children, as a novel therapeutic paradigm to treat pediatric cancers. The team will develop two types of degraders – ; proteolysis targeting chimeras (PROTACs) and molecular glue degraders. Both classes of degraders work by recruiting a ubiquitin E3 ligase to a target protein to induce target’s ubiquitination and degradation, leading to cell death. The team will focus on developing degraders for the ALK, DNAJB1::PRKACA, MYCN, EWSR1::FLI1 and PAX3::FOXO1 (or PAX7::FOXO1) oncoproteins, which have been implicated in the development and/or spread of neuroblastoma, fibrolamellar hepatocellular carcinoma, medulloblastoma, Ewings sarcoma and fusion positive rhabdomyosarcoma, respectively, in children.
Candidate Requirements:
Preferred skills:
For further information about this position please contact Professor Alessio Ciulli at a.ciulli@dundee.ac.uk. To find out more about Group please visit the group’s Website.
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