Qualification Type: | PhD |
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Location: | Newcastle upon Tyne |
Funding for: | UK Students, EU Students, International Students |
Funding amount: | £19,237 |
Hours: | Full Time |
Placed On: | 24th May 2024 |
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Closes: | 1st July 2024 |
Reference: | BI086 |
Award Summary
100% home tuition fees + annual stipend (living expenses) starting at £19,237. International candidates must fund the difference to international fees.
Overview
Are you passionate about combating antimicrobial resistance? Do you want to contribute to ground breaking research that spans continents and scientific disciplines? We invite applications for a fully-funded PhD studentship on the structural biology, microbiology, and infection of an important antimicrobial-resistant superbug – C. difficile. This unique opportunity allows you to work with leading experts in the UK and Australia, fostering international collaboration and interdisciplinary research.
C. difficile is the most frequent cause of hospital acquired infections worldwide and new, species-specific, antimicrobials are needed. C. difficile’s cell is coated by a crystalline protein surface layer which is a promising but unexploited target for new therapeutics. We recently revealed the structure of this S-layer and now want to determine how its variability affects the S-layer structure and impacts disease.
Salgado lab (UK, y1-2) - structural and functional characterisation of S-layer variants using protein crystallography, cryoEM/ET, and genetics.
Lyras lab (Australia, y3) - infection experiments to define how S-layer variation influences colonisation, infection, and disease outcomes.
This work will define the link between the S-layer and pathogenicity in C. difficile, paving the way for new therapeutic avenues.
You work alongside fellow PhD students and postdocs at Newcastle University, and access Diamond Light Source's cutting-edge facilities. Your final year at Monash University will offer exposure to diverse expertise, research environments, and outstanding facilities. Regular meetings with supervisory teams will ensure continuous support and training.
Find out more about the Salgado and Lyras labs or get in touch via Twitter/X @pssalgado, @LyrasLab, Mastodon @paulasalgado@mastodon.social or BSky @pssalgado.bsky.social.
Number Of Awards
1
Start Date
16/09/2024
Award Duration
Funding for 3 years: 2y, Newcastle University, UK + 1y, Monash University, Australia
Application Closing Date
1/07/2024
Sponsor
Supervisors
Professor Dena Lyras (Australia)
Eligibility Criteria
You must have, or expect to achieve, at least a 2:1 honours degree or international equivalent, in a subject relating to biomedical sciences (biochemistry, microbiology, chemical biology or similar). Further qualification such as an MRes is advantageous.
Fully funded for applicants with a Home fee status (UK/ EU applicants with (pre-)settled status). International applicants considered if they can fund difference to international fees. English Language: IELTS >6.5.
How To Apply
You must apply through the University’s Apply to Newcastle Portal
Registered, select ‘Create a Postgraduate Application’.
Search for ‘Course Title’ in ‘Course Search’ using the programme code 8420F, leave the ‘Research Area' field blank, select ‘PhD Biosciences (FT)' as programme of study.
In the ‘Further Details’ section please provide:
Contact Details
Professor Paula S. Salgado
NUBI, Newcastle University, UK
Professor Dena Lyras
Monash Biomedicine Discovery Institute
Monash University, Australia
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