Postdoctoral Project Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

The Tedesco laboratory (www.tedescolab.org) studies skeletal muscle stem cells and regeneration, focusing on the development of novel experimental therapies for incurable neuromuscular disorders. Their work pioneered the use of human artificial chromosomes and induced pluripotent stem (iPS) cells for muscle gene and cell therapies (Tedesco et al., Sci Transl Med 2011 and 2012; Maffioletti et al., Nat Protoc 2015; Benedetti et al., EMBO Mol Med 2017). They then developed the first disease-specific, human iPS cell-derived bioengineered muscle (Maffioletti et al., Cell Reports 2018). Recent projects investigated the use of small molecules to improve stem cell delivery (Gerli et al., Stem Cell Reports 2019) and the application of iPS cell-derived myogenesis for neuromuscular disease and therapy modelling (Steele-Stallard et al., Front Physiol 2018; Choi et al., EMBO Mol Med 2022; Pinton et al., Nat Protoc 2023).

Key Responsibilities

• Develop research projects in muscle disease modelling applied to gene therapy development both independently and as a member of a research team.
• Design, develop and refine experimental protocols in order to obtain reliable data.
• Carry out analyses, critical evaluations, and interpretations using methodologies and other techniques appropriate to area of research
• Present regular progress reports on research to members of the research group and to external audiences to disseminate and publicise research findings.
• Prepare, in consultation with supervisor, material for publication in international journals and presentations at international conferences.
• Prepare and present findings of research activity to colleagues for review purposes.
• Carry out routine administrative tasks associated with the research project/s to ensure that project/s are completed on time and within budget. These might include organisation of project meetings and documentation, financial control, risk assessment of research activities.

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 11/06/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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