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EPSRC Research Fellow

UCL - Department of Mathematics

Location: London
Salary: £42,099 to £43,205
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 1st June 2024
Closes: 28th June 2024
Job Ref: B04-04959

About the role

The main aim of this role is to develop an advanced image-based in-silico framework that provides spinal surgeons with vital information on which vertebra are most at risk of fracture in the near future, preventing unnecessary surgery on patients at low risk while more accurately identifying the high-risk patients. This will involve development of a nonlinear finite-element model of a metastatic vertebra, coupled to a tumour model (under development by collaborators in UCL Mechanical Engineering), that can predict the stress distribution generated by a set of typical loading scenarios and subsequently assess potential fracture risk. The assessed risk should enable clinicians to target the most unstable vertebra for intervention. This framework will need to be validated against in-vitro and ex-vivo experimental data, conducted by collaborators at the Universities of Birmingham and Leeds; it will also b e used to identify adverse scenarios for experimental testing. The developed framework will then be used to validate and guide the proposed minimally invasive implant design (being developed at Imperial College) within a metastatic vertebra over a range of loading scenarios to determine how it mitigates current fracture risk.

• Development and validation of a computational model framework to predict vertebral fracture risk in metastatic bone disease.

• Integrating this model with a tumour growth model (under development) to predict future fracture risk along with the minimally-invasive implant performance in terms of risk mitigation.

• Assist/support the development of experimental protocols and implant design by working side-by-side with clinical experts and our collaborators in these areas.

• Plan and perform computational simulations, as well as record, analyse and provide written and/or oral reports of the results of the simulations.

• Keep the Principal Investigators up-to-date with the progress and timing of agreed simulations.

• Liaise with other team members and stakeholders in the OncoEng programme across all institutions, including participation in engagement and dissemination events with researchers, clinicians and patient representatives.

• Devise, write, submit and, more generally, contribute to research papers to appropriate peer-reviewed journals.

• Contribute to the preparation and drafting of research bids and proposals.

• Perform some routine duties in the department and across campus as well as participate in relevant seminars etc.

• Prepare and present research findings to colleagues and at relevant national and international research conferences.

• Contribute to the overall research activities of the department as required.

• To work within financial budget constraints.

• Contribute to the induction and direction of other research staff and students as requested.

• Work toward becoming an independent researcher

• To carry out any other duties as are within the scope, spirit and purpose of the job as requested by the line manager or head of department.

The successful candidate will be teaching one undergraduate level course per year. The successful candidate will be writing and marking examinations as well as carrying out duties of 2nd examiner.

They will undertake administrative duties in line with the post. The postholder will be responsible directly to Prof Nicholas Ovenden and will work within a larger UCL OncoEng research group with Prof Rebecca Shipley (UCL Mechanical Engineering) and Prof Simon Walker-Samuel (Imaging).

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