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Postdoctoral Research Scientist - Dr Carlin

CRUK Scotland Institute

Location: Glasgow
Salary: £32,868 to £42,717 (Depending on experience) plus relocation allowance and visa costs if required
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 4th June 2024
Closes: 28th June 2024

Scotland Institute Lab: Leukocyte Dynamics Lab (Carlin)

Project Title: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.

Contract term: Fixed term for 36 months

About us

The CRUK Scotland Institute is a cancer research institute situated in Glasgow with approximately 250 researchers split across 30 research groups consisting of PIs, postdoctoral scientists, PhD students and scientific officers. It is one of Europe's leading cancer research centres, supporting cutting-edge work into the molecular mechanisms of cancer development. As well as core support from Cancer Research UK, the Institute also receives an additional third of its total income from external grants and industry collaborations. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis. Its research ethos is about excellence, honesty, openness, accountability and integrity.

Project outline

A postdoctoral position is available for an ambitious, creative and translationally minded scientist to join the Carlin group (https://www.crukscotlandinstitute.ac.uk/cruk-si-research/cruk-si-research-groups/leo-carlin-leukocyte-dynamics.html) as part of an exciting multi-disciplinary project between the Mann (Newcastle), Bird (Glasgow), Sansom (Glasgow) and Carlin (Glasgow) groups at the Scotland Institute.

This new MRC-funded project extends an established and productive partnership between these teams to interrogate the role and regulation of neutrophils in liver disease (e.g., https://doi.org/10.1136/gutjnl-2021-326259). Building on previous work (https://doi.org/10.15252/embj.2020106048) which implicates neutrophils in the development of liver senescence, we will now generate mechanistic understanding of the relationship between liver ageing and inflammation. 

You will use sophisticated genetic models of senescence and provide detailed characterisation of the immune and non-immune cellular response using a multi-parameter flow cytometry / transcriptomic / imaging approach. You will be supported by a group of scientists with expertise in these cutting-edge approaches including world class researcher-led facilities (https://www.crukscotlandinstitute.ac.uk/advanced-technologies.html). A dedicated bioinformatics post will work alongside you to maximise output.

You should hold a PhD in immunology or a related discipline with an interest in ageing and cellular senescence. Experience in high parameter single cell techniques including flow cytometry and mouse in vivo work would be highly desirable but we are happy to develop the right candidate. Enthusiasm and drive for the work are essential. This is a multi-lab project so the ideal candidate would be accountable for delivering the goals of the project with an appropriate level of independence and teamworking. Great communication skills will be key to doing this successfully.

We will review and contact promising candidates before the closing date, so please apply as soon as you are ready.

For informal enquires please contact Leo Carlin (leo.carlin@glasgow.ac.uk).

Employee Benefits

  • Competitive salary
  • 40.5 days annual leave including bank holidays (pro-rata)
  • Defined Contribution pension scheme
  • Life Insurance scheme
  • Employee Assistance Programme
  • Season ticket loan
  • Additional maternity pay at 6 month’s full pay (subject to service)
  • Shared parental leave
  • Cycle to work scheme that could save you 26-40% on a bike and accessories.
  • Access to Employee benefit schemes with discounts on supermarkets, cinema, travel and much more.
  • On-site secure parking

Closing Date for Applications: 28th June 2024 but we may contact promising candidates on a rolling basis, so please apply as soon as you are ready.

To apply, please click on the ‘Apply’ button above

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