Laboratory Research Scientist - Tybulewicz Lab

Location: The Francis Crick Institute, Midland Road, London

Short summary

The lab is studying the genetics of Down Syndrome (DS). Our aim is to identify genes on human chromosome 21 that are required in three copies to cause DS phenotypes and to establish how increased dosage of these genes causes different aspects of DS pathology. A major focus of the group is to understand why congenital heart defects occur in DS. With collaborators we are also working to understand the neurological aspects of DS.

Key Responsibilities

The role of the Laboratory Research Scientist will be to support the postdocs and PhD students working on the genetics of DS, reporting to the Group Leader, Victor Tybulewicz. The postholder will be responsible for the maintenance of multiple genetically altered mouse colonies that are being used to study the genetics of DS, and for the supply of experimental animals from these colonies to members of the group and to several collaborators outside the group. The postholder may on occasion need to organise the import and rederivation of novel genetically altered mouse strains. Furthermore, the postholder will be actively involved in studies of congenital heart defects in DS, using high resolution imaging microscopy and other cutting-edge imaging methods. The postholder may be involved in the generation of novel genetically altered mouse strains. Finally, the postholder will be responsible for general lab management, including ordering for the lab.

Key responsibilities include but are not limited to:

• Maintenance of mouse colonies
• Ordering for the lab
• General Lab management
• Supporting research projects of the postdocs and students working on the genetics of Down Syndrome
• Analysis of congenital heart defects in mouse models of Down Syndrome 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 01/09/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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