Location: | Birmingham |
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Salary: | £34,980 to £44,263 Grade 7 |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 27th August 2024 |
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Closes: | 15th October 2024 |
Job Ref: | 104014 |
Salary: Full time starting salary is normally in the range £34,980 to £44,263 with potential progression once in post to £46,974
Contract Type: Fixed Term contract up to September 2026
Background
A unique opportunity for a successful applicant to undertake research in phage display technology for enabling the discovery of peptides capable of targeting glycans.
Sugar chains, known as glycans, perform a vast array of biological functions and play key roles in various physiological and pathological events. Thus, glycans are a rich source of biomarkers for many diseases, including neurodegenerative and cardiovascular diseases, hereditary disorders, immune deficiencies, and cancer. However, a major technological bottleneck exists in the development of binding entities that can recognise glycan biomarkers with high specificity and affinity. This hampers major advances in the early and accurate diagnosis of many devastating human illnesses.
The Research Fellow will tackle the technical challenges in the development of innovative solutions to creating a highly effective high throughput selection method for peptide-based glycan binders using phase display technology. It will include incorporation of non-natural amino acids and genetic modification of bacteriophages.
This is a two-year European Research Council (ERC)-funded project, and the Research Fellow will join an interdisciplinary research team across the School of Chemical Engineering and School of Biosciences.
Role Summary
Person Specification
The successful candidate is required to have expertise in phage display technology including generation and screening of M13 Bacteriophage libraries, maintenance of phage stocks and genetic analysis of phage. In addition, expertise in genetic modification of bacteriophage, medium scale bacteriophage production and bioconjugation would be helpful.
Informal enquires can be made to Paula Mendes, email: p.m.mendes@bham.ac.uk
To download the full job description and details of this position and submit an electronic application online please click on the 'Apply' button above.
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We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working
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