Location: | London |
---|---|
Salary: | £43,210 with benefits, subject to skills and experience |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 13th September 2024 |
---|---|
Closes: | 11th October 2024 |
Job Ref: | R1880 |
Location: The Francis Crick Institute, Midland Road, London
Short summary
This is a joint collaborative project between Vivian Li Laboratory at the Francis Crick Institute and Thomas Sheahan from Oncology AstraZeneca. This is a full-time position based at the Crick with occasional collaborative visit at AZ.
Dr Li’s laboratory investigates the molecular regulation of intestinal stem cell and cancer, focusing on WNT signalling, a molecular pathway contributinRg to virtually every developmental decision in the lifetime of an organism and is hyperactivated in nearly all colorectal cancer (CRC) to promote cancer cell growth.
Dr Sheahan is a senior research scientist in the Target Validation team within AstraZeneca’s Oncology Bioscience department. The team plays a key role in identifying and validating future cancer targets across tumour types, including in the key strategic area of CRC, utilizing techniques including interactomics to aid in target discovery.
Key Responsibilities
The purpose of this role is to screen for tumour-specific Wnt drug targets by exploring differential CTNNB1 transcriptional interactomes using unbiased proteomics approaches.
In this project, some of the specific techniques include but are not limited to:
The postholder will be responsible for:
Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research.
About us
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
Type / Role:
Subject Area(s):
Location(s):