Research Fellow (x2 posts)

About us

The mission of the UCL GOS Institute of Child Health is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. Th e Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.

About the role

Applications are invited to fill two Post-doctoral Research Fellow positions in an exciting research programme based at the UCL Great Ormond Street Institute of Child Health and the UCL EGA Institute for Women’s Health. The aim of this research is to develop a novel gene therapy treatment to ameliorate the disease phenotype of a well characterised transgenic mouse model of mitochondrial disease. The successful candidate will contribute to the following aspects of the research programme: In vitro testing of codon-optimised transgene sequences in cell lines, AAV vector production, in vivo testing of AAV gene therapy treatment for a well-characterised transgen ic mouse model of mitochondrial disease Evaluation of efficacy of viral gene therapy in rescuing mitochondrial dysfunction through behavioural and tissue analyses including qPCR, Western blot and immunohistochemistry on mouse tissues, Establishing new disease outcome measures. Please check JD for detailed information.

About you

Applicants must have a higher degree in a relevant discipline (Neuroscience or genetics or gene therapy or another relevant subject area) at PhD level Experience with mouse in vivo research is essential and in mouse in vivo gene therapy desirable A Home Office animal licence is strongly desirable Experience in viral vector production and mouse in vivo gene therapy methodologies are strongly desirable Molecular biology, cell biology, western blot and immunohistochemical experience is essential.

What we offer:

Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diver sity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusion/ If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference B02-07660 

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