Post-doctoral Research Assistant

Applications are sought for an experienced electrophysiologist to drive a project funded by the British Heart Foundation studying the regulation of Kv7.1 channels by βγ G proteins. This work builds upon a phenomenon identified by the research group^1,2 and is concerned with an ion channel important in cardiac rhythmicity. The successful candidate will be expected to drive the generation and analysis of data, presentation conferences, contribute to writing of papers and future grant applications. This is a new area of research, so a positive and flexible mind set is required to advance the project.

References:

1 Stott JB, Povstyan OV, Carr G, Barrese V, Greenwood IA. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proc Natl Acad Sci U S A. 2015 May 19;112(20):6497-502. doi: 10.1073/pnas.1418605112. PMID: 25941381; PMCID: PMC4443360.

2. Stott JB, Greenwood IA. G protein βγ regulation of KCNQ-encoded voltage-dependent K channels. Front Physiol. 2024 Apr 9;15:1382904. doi: 10.3389/fphys.2024.1382904. PMID: 38655029; PMCID: PMC11035767.

Key attributes of the successful applicant include:

• BSc and PhD in an appropriate field
• Experience at recording ion channel currents from mammalian heterologous expression systems especially whole cell and inside-out excised patch recordings.
• Experience with cell culture techniques including freezing and reanimation of cell lines.
• Experience with molecular manipulation of plasmids to introduce amino acid changes or protein truncations.
• Also desirable is experience with protein biochemistry techniques such as immunocytochemistry, co-immunoprecipitation and proximity ligation assay. 

For further information about this position contact Prof Iain Greenwood at grenwood@citystgeorges.ac.uk and to apply click the 'Apply' button above.

St George’s School of Health and Medical Sciences is committed to promoting equality, diversity and inclusion in all its activities, processes, and culture for our whole community, including staff, students and visitors. 

We welcome applications regardless of age, caring responsibilities, disability, gender identity, gender reassignment, marital status, nationality, pregnancy, race and ethnic origin, religion and belief, sex, sexual orientation and socio-economic background.  

Please quote reference:  113-25-R

Closing date: Tuesday 13 May 2025         

Interview date: TBC

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