BRF GeMS Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Salary: From £37,300 with benefits, subject to skills and experience

About us…  

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. 

To learn more about the Crick, click here.

About the role… 

The Genetic Modification Services (GeMS) provide a breadth of specialist skills and resources for the design, creation, production, storage and use of genetically altered animals, germplasms and cell lines together with ancillary techniques.

The post-holder will join the genetic modification team and assist in the design and generation of molecular reagents used in both in vivo and in vitro genetic engineering experiments for the generation of animal and disease models and the subsequent genetic validation of the resulting mutant strains.

You will participate in the creation of new animal models, taking a lead role towards the development of a subset of projects. 

As a BRF GeMS Research Scientist at the Crick, you will: 

• Assist in the design, generation of reagents and validation of new genetically modified alleles.
• Perform core molecular biology techniques including LR-PCR, PCR, digital droplet or qPCR, molecular cloning, NGS sequencing technologies, genotyping and sequence analysis.
• Maintenance of mESC cultures and perform in vitro CRISPR facilitated and classical gene targeting experiment using electroporation, nucleofection and lipofection. Engage in out of hours cell culture work rota.
• Participate in the creation of new animal models, taking a lead role towards the development of a subset of projects; working towards agreed deadlines, identifying and troubleshooting at each step, seeking support when required.
• Maintain records, ensuring your own scientific work is always carried out accurately and efficiently, adhering to legal frameworks. 

About you…  

You will bring….

• A degree or equivalent in a biological subject.
• Experience in a relevant position, particularly in molecular biology and mammalian cell culture.
• Understanding CRISPR-CAS9 design and associated techniques.
• Experience of using genome browsers, DNA analysis software and CRISPR CAS9 guide on/off target specificity software. 

To see the complete Job Description click here for more info 

To see the complete Job Description, click here

See more about team/Group Leader here 

About Working at the Crick… 

Our values  

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently. 
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. 
• We are collegial. We show respect for one another, work cooperatively and support the wider community. 

At the Crick, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. If you need assistance with your application, please contact weronika.kucala@crick.ac.uk

To read more about our EDI approach, click here.   

What will you receive?  

We value our team members and are proud to offer an extensive range of benefits to support their well-being and development. You can find out more about what we offer here.

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