Research Fellow

About us

The UK Dementia Research Institute (UK DRI) is the biggest UK initiative supporting research to fill the major knowledge gap in our basic understanding of the diseases that cause dementia.

Research from UK DRI at UCL covers the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies put to the test.

The Buche Laboratory, based in the UK DRI at UCL, focuses on uncovering how molecular, cellular, and neural circuit changes - particularly involving tau and amyloid proteins - lead to memory loss and cognitive decline in Alzheimer’s disease. Using advanced techniques such as microscopy, electrophysiology, optogenetics, and molecular biology, the goal is to better understand disease mechanisms and contribute to the development of effective treatments.

About the role

We offer an exciting opportunity to work independently on a high impact, state-of-the-art project in a cutting-edge research laboratory at the UK Dementia Research Institute at UCL. We are seeking an exceptional individual to lead a innovative research programme aimed at understanding - and ultimately reversing - neuronal and circuit dysfunction in Alzheimer’s disease. The focus will be on linking early, cell-type-specific molecular alterations to large-scaleneural circuit impairments in mouse models, and on testing gene-therapeutic approaches to restore normal function.

The project will utilise advanced techniques such as in vivo two-photon calcium imaging and/or Neuropixels electrophysiology to record neuronal activity across large populations of cells. A variety of experimental and analytical approaches will be applied to interrogate the mechanisms of dysfunction and evaluate novel therapeutic interventions.

The post is available from 01 July 2025 and funded by the UK DRI until 30 April 2027 in the first instance.

For a full job description and to apply for this role please visit UCL’s online recruitment portal (https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs) and search using vacancy reference B02-08769.

About you

You will hold a PhD in neuroscience, engineering, computer science, mathematics, physics, or a related field, and have practical experience with in vivo two-photon calcium imaging and/or Neuropixels electrophysiology. A strong background in analytical and/or statistical analysis, along with proficient programming and coding skills, is essential for the role. Excellent interpersonal, collaboration, and communication skills are also required.

What we offer

As well as the exciting opportunities this role presents, we also offer great benefits; visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Please visit https://www.ucl.ac.uk/human-resources/conditions-service-research-teaching-and-professional-services-staff for more information.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. 12% of Institute staff are actively working on EDI initiatives; visit https://www.ucl.ac.uk/ion/equality-diversity-inclusion for more information about what we’re doing. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce; these include people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender diverse people in all roles, and women in Grade 9 and 10 roles.

Customer advert reference: B02-08769

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