Postdoctoral Research Associate

Location: Peter Medawar Building for Pathogen Research, 3 S Parks Rd, Oxford OX1 3SY

Current conceptual frameworks for antigenically diverse pathogens either ignore or dismiss the existence of protective epitopes of limited variability, with most efforts to make “universal” vaccines being focused on artificially trying to establish potent responses to conserved epitopes. This is based on the dogma that all epitopes under strong immune selection are inevitably highly variable. Our research group has shown, by contrast, that the dynamics of antigenically diverse pathogens is driven by naturally acquired immunity against epitopes of limited variability (ELV), thereby opening up the possibility of making “universal” vaccines by targeting these epitopes.

We have validated this methodology for the influenza virus (https://www.nature.com/articles/s41467-018-06228-8) and the technology has been patented and licensed. We are currently seeking to apply such a pipeline to other important antigenically diverse pathogens thereby identifying vaccine candidates of limited variability but high potency to protect against the associated infectious diseases and potential pandemic threats. The focus of this project is to explore the possibility of using this methodology to develop a pan-corona virus vaccine in readiness for future coronavirus pandemics. You will be expected to carry out experimental work, including studies animal studies, to explore the potential of candidates identified in-silico to serve as components of such a vaccine, as well as to assist eventually with the design of the vaccine itself and liaise with appropriate partners to conduct clinical trials.    

The University of Oxford is committed to equality and valuing diversity. All applicants will be judged on merit, according to the selection criteria.

This post is full time with a start date to be agreed with the successful candidate.

The closing date for applications is 12.00 noon on 25th June, interviews are likely to be scheduled for July.

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