Location: | Cambridge |
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Salary: | £37,174 to £45,413 per annum |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 3rd June 2025 |
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Closes: | 17th June 2025 |
Job Ref: | PH46147 |
Applications are invited for a Research Associate to join the Department of Biochemistry, under the supervision of Dr Antony Jackson. The successful candidate will conduct a BHF-funded research project on voltage-gated sodium channels, particularly the heart-specific channel, Nav1.5. The specific question will focus on the functional effects of small molecule drugs on Nav channel behaviour. The work will entail electrophysiological analysis, structural biology approaches such as cryo electron microscopy, computational modelling, cell biology and biochemistry.
The role holder will therefore need to possess expert knowledge on the structure and function of voltage-gated sodium channels and skills in both manual and automated patch clamp electrophysiology. Molecular biology experience for the cloning, site-directed mutagenesis and expression of Nav channels will be required, together with experience of computational modelling for drug docking to aid mutagenesis experiments.
The successful candidate will help design, conduct and interpret experiments in discussion with the PI and Co-PI and other members of the research team. Research will be presented at group meetings and at research conferences and will be published in journal articles prepared by the role holder, with support from other team members.
Candidates should hold a PhD in Biochemistry or another relevant subject.
Fixed-term: The funds for this post are available from 7th November 2025 until 30th June 2027, in the first instance.
To apply online for this vacancy and to view further information about the role, please click the 'Apply' button above.
Informal enquiries are welcome to be sent to Dr Antony Jackson: apj10@cam.ac.uk
For queries regarding the application process, please contact: personnel@bioc.cam.ac.uk
Please quote reference PH46147 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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