Research Associate for biophysical and structural characterisation of NMD complexes
University of Bristol - Biochemistry
| Location: | Bristol |
|---|---|
| Salary: | £38,249 to £44,128 Grade I, per annum |
| Hours: | Full Time |
| Contract Type: | Fixed-Term/Contract |
| Placed On: | 26th June 2025 |
|---|---|
| Closes: | 10th July 2025 |
| Job Ref: | ACAD108173 |
The role
The Berger-Schaffitzel team is seeking to fill a Post-Doctoral Research Associate post at the School of Biochemistry, University of Bristol, UK.
You will research complexes involved in nonsense-mediated mRNA decay (NMD) with the aim to understand the molecular basis of NMD malfunction caused by UPF3B mutations which lead to neurodevelopmental disorders in the affected families. You will biophysically characterise the impact of UPF3B-disease causing mutations and solve cryo-EM structures of UPF3B in complex with other NMD factors.
You will benefit from the cutting-edge molecular biology, biochemistry, structural biology and biophysics expertise and facilities in Bristol. Moreover, you will capitalize on our eukaryotic expression platform and synergize with academic collaborators. In addition, you will participate in a vibrant and dynamic, inclusive and equitable research environment in a laboratory developing and applying cutting-edge technology to generate new knowledge and biological insights in a top 10 UK University, in one of the best cities to live in the UK.
What will you be doing?
You will be part of a cutting-edge research team characterising NMD factors biophysically and structurally to understand the molecular mechanisms of early events that lead to the degradation of nonsense mRNAs. Showing a high degree of independence, you will drive an ambitious research programme to determine the structure and mechanism of NMD factor complexes.
For information about the Berger-Schaffitzel lab and our research activities please follow:
https://research-information.bris.ac.uk/en/persons/christiane-h-berger-schaffitzel
https://www.linkedin.com/in/christiane-berger-schaffitzel-a36178159/?originalSubdomain=uk , and
Christiane Schaffitzel - Google Scholar
You should apply if
- Enjoy working on cutting-edge projects in protein science and structural biology
- Are a dedicated team player in an international, dynamic, diverse and equitable team
- Have experience with baculovirus insect cell expression and protein purification
- Have experience with biophysics (MST, SPR, SEC, fluorescence anisotropy)
- Have experience with cryo-EM and image processing
- Have experience with RNA-protein complexes
- Have a basic knowledge in translational control mechanisms
Additional information
For informal enquiries please contact:
Christiane Berger-Schaffitzel (cb14941@bristol.ac.uk) or
Dakang Shen (dakang.shen@bristol.ac.uk)
Contract type: Fixed term until 28/03/2026
This advert will close at 23:59 UK time on Thursday 10th July 2025
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Available documents
- ACAD108173 - Research Associate - Job Description.pdf
- Further Particulars_Faculty of Health & Life Sciences.pdf
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