Research Associate in Cell and Molecular Biology

Job description:

We have an exciting opportunity for a highly motivated and talented Postdoctoral Research Associate with a passion for cell and molecular biology to join a collaborative British Heart Foundation-funded Research Project within the groups of Dr Ridger and Professor Francis at University of Sheffield (School of Medicine and Population Health) and Professor Jørgensen at the University of Cambridge (The Victor Phillip Dahdaleh Heart & Lung Research Institute). Atherosclerosis remains a leading cause of morbidity and mortality worldwide.  This exciting project will investigate the interplay between the innate immune system and smooth muscle cells within developing atherosclerotic plaques. It will focus on the critical role of neutrophil derived extracellular vesicles (EVs) in the initiation and progression of atherosclerotic plaque development and build on previous work by the group (Gomez et al Nat Commun 11, 214 (2020). https://doi.org/10.1038/s41467-019-14043-y).

You will employ a multi-disciplinary approach, integrating advanced cell biology techniques, relevant mouse models of atherosclerosis, cutting-edge single-cell RNA sequencing and bioinformatics to dissect the mechanisms by which EVs contribute to this complex cardiovascular disease. The project involves a 4-month placement at the University of Cambridge (cost of travel and accommodation covered) to carry out the single-cell RNA sequencing. You will be responsible for designing and executing experiments, analysing and interpreting complex data, disseminating the results at conferences and in publications as well as contributing to grant writing and project development. Other key aspects of the role include mentoring junior researchers and fostering a collaborative lab environment.

Candidates should have a PhD and a track record of success in molecular and cellular biology research. Significant experience in human cell culture, molecular biology, and data analysis is required. Experience in scRNAseq and in vivo models of atherosclerosis would be an advantage. You should be able to demonstrate excellent analytical and problem-solving skills as well as the ability to work independently and as part of a team.

The School of Medicine and Population Health at the University of Sheffield offers a stimulating and collaborative research environment within a Russell Group university. The School is home to cutting-edge research across diverse areas, from fundamental cell and molecular biology to public health and clinical trials, offering opportunities to contribute to impactful discoveries that address global health challenges. This role offers a competitive salary and benefits package commensurate with experience and the chance to work at a world-renowned institution in a beautiful and vibrant city in the heart of the UK. We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

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