Location: | London |
---|---|
Salary: | £48,056 to £56,345 per annum |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 18th July 2025 |
---|---|
Closes: | 17th August 2025 |
Job Ref: | MED05354 |
About the role
This is an MRC-funded post part of the project: ‘Investigating and targeting microglial senescence in Alzheimer’s disease (AD)’. This is an exciting project funded by the MRC, using human iPSC-derived microglia to explore the functional consequences of senescence. The applicant will work at the Senescence group led by Prof. Jesus Gil at Imperial College and interact closely with a consortium of groups, including those of Prof. Diego Gomez Nicola (University of Southampton) and Dr Emma Mead (CMD, Oxford).
What you would be doing
The applicant will be working in the Senescence Group at MRC LMS, led by Prof. Jesus Gil.
Our lab has contributed to understanding the role of senescence as a tumour suppressor mechanism (Collado et al. Nature 2005), in limiting iPSC reprogramming (Banito et al. Genes Dev 2009) or activating immune surveillance (Kang et al. Nature 2011). We have also identified molecular mechanisms controlling senescence (Gil et al. Nat Cell Biol 2004; Tordella et al. Genes Dev 2016), the inflammatory phenotype associated with senescence (Acosta et al. Cell 2008; Acosta et al. Nat Cell Biol 2013; Herranz et al. Nat Cell Biol 2015; Georgilis et al. Cancer Cell 2018) ,how to target senescent cells (Guerrero et al. Nat Metabolism 2019; Guerrero et al. Nat Aging 2022; McHugh et al. Nat Cell Biol 2023) and the relationship between senescence and immune cells (Haston et al. Cancer Cell 2023; Reen et al. Sci Adv 2025). In this position, the applicant will study senescence responses in human iPSC-derived microglia and use those cells to identify drugs that could be used in the context of AD.
What we are looking for
The successful candidate should be highly motivated, committed and have clear career goals. Experience with iPS, advanced cell culture systems, senescence or drug screenings is highly desirable. All applicants should have a PhD degree in life sciences or equivalent experience, and at least one first-author primary publication published. Availability to start working as soon as possible is essential.
What we can offer you
Further information
This is a full-time, fixed-term post for 18 months.
Available documents
Attached documents are available under links.
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.
We reserve the right to close the advert prior to the closing date stated should we receive a high volume of applications.
If you encounter any technical issues while applying online, please don't hesitate to email us at support.jobs@imperial.ac.uk. We're here to help.
Type / Role:
Subject Area(s):
Location(s):