Research Associate

Job description:

Applications are invited for the post of Research Associate to join Sheffield’s Translational Neuro-Oncology Research Group led by Prof. Spencer Collis (Science), Mr. Ola Rominiyi (Translational) and Mr. Yahia Al-Tamimi (Clinical) based within the Division of Clinical Medicine at the University of Sheffield’s Medical School. The overarching research goal of the Sheffield’s Translational Neuro-Oncology team is to identify and develop new targets and treatment regimens to improve the clinical management of high-grade glioblastomas and other related brain tumours. More information on the Collis and Rominiyi laboratories can be found on https://www.sheffield.ac.uk/medicine/people/oncology-metabolism/spencer-collis, and https://www.sheffield.ac.uk/smph/people/clinical-medicine/ola-rominiyi.

We are seeking a highly motivated, practically skilled, well organised and semi-independent individual to work on a 3-year YCR-funded project to carry out mechanistic interrogation of intra/inter-tumoural heterogeneity within the DNA Damage response and how this impacts therapeutic resistance to in order to develop more effective pan-tumour treatment strategies. This will involve investigating spatially-mediated molecular divergence in response to chemo/radio-therapy and therapeutic/preclinical DDR inhibitors within a cohort of matched GSC heterogeneity models within the Sheffield Living Biobank of patient-derived primary glioma stem cell-like (GSC) culture models. These findings will synergise with our spatial bioinformatic profiling of these tumour models and will be used to develop potential DDR-targeted combination therapies with as much pan-tumour efficacy as possible.

You will be a practically skilled, well organised, flexible and committed Postdoctoral Researcher who will join a diverse laboratory team to conduct laboratory research on a semi-independent basis under the direction of Prof. Collis and Mr. Rominiyi. You will be expected to; design, execute and evaluate experiments; keep excellent experimental records; prepare reports regularly and feed back to other members of the research group. You are also expected to contribute to the preparation of scientific manuscripts, attend and deliver seminars/lab meetings, help supervise undergraduate students and advise post-graduate research students as necessary as part of a collaborative research team. The successful candidate should be strongly motivated, self-driven, able to accept direction and be an excellent team player. Excellent communication and interpersonal skills are expected. You should have a PhD (or be close to completion) in molecular or cell biology or have appropriate equivalent experience. You will have experience in human cell culture growth and manipulation (preferrable stem cell culture), western blotting, immunohistochemistry, cell survival assays (preferrable clonogenic assays). Expertise in cancer cell biology and either stem cell biology and/or DNA damage response/repair pathways would be advantageous, but not necessary.

The Division of Clinical Medicine brings together researchers to translate scientific discoveries into clinically meaningful advances. More information about the Department can be found here: https://www.sheffield.ac.uk/medicine/department-oncology-metabolism. The Medical School was recently successful in achieving a silver award for its achievement and hard work promoting gender equality: https://www.sheffield.ac.uk/medicine/athena-swan.

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