Senior Postdoctoral Researcher - Computational Genomics

Location: Ludwig Institute for Cancer Research, Old Road Campus Research Building, Oxford, OX3 7DQ

Salary: - Research Grade 8: £48,235 - £57,255 with a discretionary range to £64,228 p.a. (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata).

Are you passionate about taking a lead role in a cutting-edge project at the intersection of genomics, computational biology, and haematological cancer?

We have an exciting opportunity for a Senior Postdoctoral Researcher to be a part of a collaborative interdisciplinary initiative at the Ludwig Institute for Cancer Research which aims to characterize the epignetic landscapre of MPN and sAML, uncover the molecular mechanisms underlying disease progression and treatment resistance and identify novel therapeutic targets.

You will take a lead on development of computational approaches to integrate multi-omics data from patient samples, including DNA methylation, histone modifications, single-cell transcriptomics and chromatin accessibility. You will contribute to the study and sequencing design, collaborate with experimental biologists to validate the hypotheses, and advise and supervise computational staff and students. You will write research articles and present the results at national and international conferences.

It is essential that you hold a PhD/DPhil in computational biology, genomics, bioinformatics, computer science, statistics, or a related field together with strong programming skills in Python, R, or similar languages, and proficiency in high-performance computing. You will have experience in large-scale genomic data analysis. You will be able to demonstrate how to organise and prioritise work efficiently, work independently and deliver high quality novel research in relevant fields. It is desirable that you have knowledge of epigenetic modifications and mechanisms and experience in single-cell data analysis.

Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.

This position is offered full time on a fixed term contract for 36 months and is funded by Ludwig.

Only applications received before 12 midday on Friday 29^th August 2025 will be considered. Please quote 178673 on all correspondence.

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