Research Associate in Circadian Mechanisms in Cardiometabolic Disease

We are seeking a highly motivated and talented scientist to join our MRC-funded research programme investigating how disruption of the circadian clock impacts energy metabolism and contributes to metabolic disease. You will play a key role in defining how circadian processes in the liver and other tissues regulate lipid metabolism and mitochondrial function, under both normal and perturbed conditions (e.g. dietary or environmental challenges). This exciting project builds on our recent findings (e.g. Downton et al., PNAS; Hayter et al., Nature Communications; West et al., Nature Communications), which demonstrate that circadian disruption—caused by simulated shift work, diet-induced obesity, or chronic inflammation—leads to aberrant liver function and accumulation of harmful lipid species such as ceramides. Working within a vibrant circadian research community in Manchester, you will employ cutting-edge in vivo and in vitro models, advanced physiological phenotyping, and multi-omic and flux metabolomic approaches. You will also collaborate with leading partners at the Universities of Oxford and Aberdeen. You will have a PhD (or near completion) in a relevant biological or biomedical discipline, and bring experience in mammalian physiology, circadian biology, and/or energy metabolism, strong research experience, analytical and communication skills, and enthusiasm for interdisciplinary and collaborative research.

Due to the nature of the funding, KTP Associates who have already completed a KTP are not eligible to apply.

As this role involves research at a postgraduate level, applicants who are not an EEA national or a national of an exempt country and who will require sponsorship under the Skilled Worker route of the UK Visas and Immigration’s (UKVI) Points Based System in order to take up the role, will be required to apply for an Academic Technology Approval Scheme (ATAS) Certificate and will need to obtain this prior to making any official visa application UKVI)

Enquiries about the vacancy, shortlisting and interviews:

Name: David Bechtold

Email: david.bechtold@manchester.ac.uk

General enquiries:

Email: People.recruitment@manchester.ac.uk

Technical support: jobseekersupport.jobtrain.co.uk/support/home

This vacancy will close for applications at midnight on the closing date.

Please see the link below for the Further Particulars document which contains the person specification criteria.

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