Postdoctoral Project Research Scientist – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Contract: Fixed Term/ Full time 2 year contract

Short summary

We are looking for a creative and enthusiastic Postdoctoral Project Research Scientist to join the C Swanton Cancer Evolution and Genome Instability Laboratory

This lab studies how cancers evolve in the body to spread and become resistant to therapy and discovers new ways to treat them more effectively.

The Project

As a PPRS you will investigate the role of cell lineage upon lung cancer initiation, both in homeostasis and in the context of challenge with non-mutagenic carcinogens. You will seek to understand which cells within the lung are most susceptible to air pollutants and the routes they take to tumourigenesis. Additionally, you will contribute to research which is committed to advancing our understanding of the biology of lung tumour evolution.

Key Responsibilities

You will need: 

• To decipher evolutionary mechanisms during lung cancer initiation and progression using data from animal models.
• To employ novel informatics techniques based on evolutionary principles to the analysis of tumour subclonal evolution.
• To understand cancer biology and the relevant literature sufficiently to take own ideas forward as lead author on new projects.
• To work within the informatics team of the TRACERx and TRACERx EVO programs.
• To record all experiments and code in an accurate timely, clearly presented and reproduceable manner
• To contribute to the dissemination of scientific results by means of writing papers for publication and presentations.

Please click here to read about the lab

See the full job description here

About you

You will have:

• PhD*
• Previous experience with cancer genomics NGS data*
• Fluent in R or Python*
• Evidence of significant contribution to high impact publications*
• Experience with HPC environments
• Experience of collaboration with clinicians and wet lab scientists or work within a multi-disciplinary environment
• Experience in evolutionary biology or cancer biology 

*Minimum Criteria 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

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